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Table 1 Age-adjusted mean values and proportions by alkaline phosphatase levels

From: Association between alkaline phosphatase and hypertension in a rural Japanese population: The Nagasaki Islands study

  ALP quartiles  
Q1 (low) Q2 Q3 Q4 (high) P value
Men
  Median values for serum ALP (U/l) 172 209 250 318  
  Number at risk 205 215 207 208  
  Age (years) 63.9 ± 10.0 63.2 ± 11.5 65.3 ± 10.2 65.7 ± 10.2  
  Systolic blood pressure (mmHg) 140 142 143 141 0.504
  Diastolic blood pressure (mmHg) 84 85 86 85 0.390
  Antihypertensive medication use (%) 27 22 25 26 0.735
  Thyroid disease (%) 0.0 0.5 1.0 0.0 0.300
  Body mass index (kg/m2) 23.7 23.8 23.6 23.3 0.337
  Current drinker (%) 62 53 46 45 0.002
  Current smoker (%) 20 23 27 29 0.105
  Serum triglycerides (mg/dl) 128 138 153 142 0.044
  Diabetes (%) 8 7 11 12 0.267
  Serum aspartate aminotransferase (AST) (IU/l) 24 25 25 26 0.061
  Serum γ-glutamyltranspeptidase (γ-GTP ) (IU/l) 36 41 51 60 <0.001
  Serum creatinine, (mg/dl) 0.90 0.93 0.92 0.91 0.562
  Glomerular filtration rate (ml/minute/1.73 m2) 70.3 68.4 68.5 70.7 0.411
Women
  Median values for serum ALP (U/l) 170 220 263 337  
  Number at risk 465 458 467 456  
  Age (years) 56.4 ± 12.8 63.7 ± 10.8 64.3 ± 9.6 65.8 ± 9.2  
  Systolic blood pressure (mmHg) 137 140 141 142 <0.001
  Diastolic blood pressure (mmHg) 80 83 84 84 <0.001
  Antihypertensive medication use (%) 26 25 24 31 0.029
  Thyroid disease (%) 0.4 0.7 1.3 0.9 0.534
  Body mass index (kg/m2) 22.6 22.9 23.2 23.1 0.083
  Current drinker (%) 13.3 13.4 10.2 11.1 0.338
  Current smoker (%) 3.6 3.3 4.7 4.5 0.682
  Serum triglycerides (mg/dl) 113 118 127 133 <0.001
  Diabetes (%) 5.8 5.4 5.6 7.1 0.689
  Serum aspartate aminotransferase (AST) (IU/l) 21.4 21.9 22.0 23.1 0.011
  Serum γ-glutamyltranspeptidase (γ-GTP)IU/l) 20 24 25 31 <0.001
  Serum creatinine, (mg/dl) 0.724 0.715 0.716 0.724 0.740
  Glomerular filtration rate (ml/minute/1.73 m2) 66.7 67.7 67.7 66.5 0.574
  1. Age presented as mean ± standard deviation. Serum alkaline phosphatase (ALP) levels for quartiles were <194 U/l, 194 to 228 U/l, 229 to 275 U/l, and >275 U/l for men and <199 U/l, 199 to 240 U/l, 241 to 290 U/l, and >290 U/l for women.