Men
|
Median values for serum ALP (U/l)
|
172
|
209
|
250
|
318
| |
Number at risk
|
205
|
215
|
207
|
208
| |
Age (years)
|
63.9 ± 10.0
|
63.2 ± 11.5
|
65.3 ± 10.2
|
65.7 ± 10.2
| |
Systolic blood pressure (mmHg)
|
140
|
142
|
143
|
141
|
0.504
|
Diastolic blood pressure (mmHg)
|
84
|
85
|
86
|
85
|
0.390
|
Antihypertensive medication use (%)
|
27
|
22
|
25
|
26
|
0.735
|
Thyroid disease (%)
|
0.0
|
0.5
|
1.0
|
0.0
|
0.300
|
Body mass index (kg/m2)
|
23.7
|
23.8
|
23.6
|
23.3
|
0.337
|
Current drinker (%)
|
62
|
53
|
46
|
45
|
0.002
|
Current smoker (%)
|
20
|
23
|
27
|
29
|
0.105
|
Serum triglycerides (mg/dl)
|
128
|
138
|
153
|
142
|
0.044
|
Diabetes (%)
|
8
|
7
|
11
|
12
|
0.267
|
Serum aspartate aminotransferase (AST) (IU/l)
|
24
|
25
|
25
|
26
|
0.061
|
Serum γ-glutamyltranspeptidase (γ-GTP ) (IU/l)
|
36
|
41
|
51
|
60
|
<0.001
|
Serum creatinine, (mg/dl)
|
0.90
|
0.93
|
0.92
|
0.91
|
0.562
|
Glomerular filtration rate (ml/minute/1.73 m2)
|
70.3
|
68.4
|
68.5
|
70.7
|
0.411
|
Women
|
Median values for serum ALP (U/l)
|
170
|
220
|
263
|
337
| |
Number at risk
|
465
|
458
|
467
|
456
| |
Age (years)
|
56.4 ± 12.8
|
63.7 ± 10.8
|
64.3 ± 9.6
|
65.8 ± 9.2
| |
Systolic blood pressure (mmHg)
|
137
|
140
|
141
|
142
|
<0.001
|
Diastolic blood pressure (mmHg)
|
80
|
83
|
84
|
84
|
<0.001
|
Antihypertensive medication use (%)
|
26
|
25
|
24
|
31
|
0.029
|
Thyroid disease (%)
|
0.4
|
0.7
|
1.3
|
0.9
|
0.534
|
Body mass index (kg/m2)
|
22.6
|
22.9
|
23.2
|
23.1
|
0.083
|
Current drinker (%)
|
13.3
|
13.4
|
10.2
|
11.1
|
0.338
|
Current smoker (%)
|
3.6
|
3.3
|
4.7
|
4.5
|
0.682
|
Serum triglycerides (mg/dl)
|
113
|
118
|
127
|
133
|
<0.001
|
Diabetes (%)
|
5.8
|
5.4
|
5.6
|
7.1
|
0.689
|
Serum aspartate aminotransferase (AST) (IU/l)
|
21.4
|
21.9
|
22.0
|
23.1
|
0.011
|
Serum γ-glutamyltranspeptidase (γ-GTP)IU/l)
|
20
|
24
|
25
|
31
|
<0.001
|
Serum creatinine, (mg/dl)
|
0.724
|
0.715
|
0.716
|
0.724
|
0.740
|
Glomerular filtration rate (ml/minute/1.73 m2)
|
66.7
|
67.7
|
67.7
|
66.5
|
0.574
|