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Table 2 Serum non-HDL cholesterol levels classified by smoking status and Mt5178 C/A genotype

From: Difference in effects of cigarette smoking or alcohol consumption on serum non-high-density lipoprotein cholesterol levels is related to mitochondrial DNA 5178 C/A polymorphism in middle-aged Japanese men: a cross-sectional study

  Smoking status P for trend
  Never- or ex-smokers 1-20 cigarettes smoked per day >20 cigarettes smoked per day  
Mt5178C N = 142 N = 70 N = 27  
non-HDL cholesterol 149.2 ± 3.0 144.7 ± 4.3 158.6 ± 7.0 P = 0.557
non-HDL cholesterol 148.8 ± 3.0 145.4 ± 4.3 160.5 ± 7.0 P = 0.333
non-HDL cholesterol 151.8 ± 4.6 146.8 ± 5.2 162.3 ± 7.7 P = 0.500
Mt5178A N = 92 N = 40 N = 23  
non-HDL cholesterol 139.9 ± 3.5 145.8 ± 5.3 169.3 ± 6.9** P < 0.001
non-HDL cholesterol 139.0 ± 3.4 149.4 ± 5.2 166.7 ± 6.7* P < 0.001
non-HDL cholesterol 141.2 ± 5.4 150.1 ± 6.1 168.0 ± 8.1* P < 0.001
  1. non-HDL cholesterol levels are given as least-square mean ± SE adjusted for age and body mass index; non-HDL cholesterol levels are given as least-square mean ± SE adjusted for age, body mass index, alcohol consumption, coffee consumption and antihypertensive medication use. Bonferroni correction for multiple comparisons was applied. *P < 0.005 vs never- or ex-smokers, **P < 0.001 vs never- or ex-smokers, §P < 0.001 vs current smokers who smoked 1 to 20 cigarettes per day. HDL, high-density lipoprotein; Mt5178C, mitochondrial DNA 5178 cytosine; Mt5178A, mitochondrial DNA 5178 adenosine.