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Table 3 Odds ratios and 95% confidence intervals for high levels of serum non-HDL cholesterol by Mt5178 C/A genotype and smoking status

From: Difference in effects of cigarette smoking or alcohol consumption on serum non-high-density lipoprotein cholesterol levels is related to mitochondrial DNA 5178 C/A polymorphism in middle-aged Japanese men: a cross-sectional study

Genotype and number of cigarettes smoked daily

Frequency

OR (95% CI)

Adjusted OR†(95% CI)

Adjusted OR‡(95% CI)

Normal levels of serum non-HDL cholesterol

High levels of serum non-HDL cholesterol

 

non-HDL cholesterol <160 mg/dl

non-HDL cholesterol ≥160 mg/dl

   

Mt5178C

     

0 (never- or ex-smokers)

95 (66.9)

47 (33.1)

1 (reference)

1 (reference)

1 (reference)

1-20

46 (65.7)

24 (34.3)

1.055 (0.576-1.931)

1.079 (0.577-2.016)

0.955 (0.491-1.857)

>20

16 (59.3)

11 (40.7)

1.390 (0.598-3.230)

1.436 (0.591-3.492)

1.498 (0.596-3.765)

   

P for trend = 0.495

P for trend = 0.403

P for trend = 0.619

Mt5178A

     

0 (never- or ex-smokers)

71 (77.2)

21 (22.8)

1 (reference)

1 (reference)

1 (reference)

1-20

24 (60.0)

16 (40.0)

2.254 (1.015-5.007)*

3.035 (1.269-7.259)*

2.580 (1.027-6.481)*

>20

8 (34.8)

15 (65.2)

6.339 (2.364-17.00)***

6.191 (2.258-16.97)***

5.681 (2.022-15.96)**

   

P for trend < 0.001

P for trend < 0.001

P for trend < 0.001

 

non-HDL cholesterol <190 mg/dl

non-HDL cholesterol ≥190 mg/dl

   

Mt5178C

     

0 (never- or ex-smokers)

126 (88.7)

16 (11.3)

1 (reference)

1 (reference)

1 (reference)

1-20

62 (88.6)

8 (11.4)

1.016 (0.413-2.503)

1.071 (0.427-2.686)

0.890 (0.334-2.376)

>20

22 (81.5)

5 (18.5)

1.790 (0.595-5.385)

1.943 (0.6.5-6.244)

2.210 (0.654-7.469)

   

P for trend = 0.397

P for trend = 0.313

P for trend = 0.368

Mt5178A

     

0 (never- or ex-smokers)

86 (93.5)

6 (6.5)

1 (reference)

1 (reference)

1 (reference)

1-20

35 (87.5)

2 (12.5)

2.048 (0.587-7.148)

2.420 (0.655-8.944)

2.815 (0.692-11.45)

>20

16 (69.6)

7 (30.4)

6.271 (1.862-21.11)**

6.081 (1.772-20.86)**

6.315 (1.715-23.25)*

   

P for trend = 0.004

P for trend = 0.006

P for trend = 0.007

  1. †OR adjusted for age and body mass index. ‡OR adjusted for age, body mass index, habitual alcohol consumption, coffee consumption and antihypertensive medication. *P < 0.05, **P < 0.005, ***P < 0.001. CI, confidence interval; HDL, high-density lipoprotein; Mt5178C, mitochondrial DNA 5178 cytosine; Mt5178A, mitochondrial DNA 5178 adenosine; OR, odds ratio.
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Journal of Physiological Anthropology

ISSN: 1880-6805

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