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Table 3 Odds ratios and 95% confidence intervals for high levels of serum non-HDL cholesterol by Mt5178 C/A genotype and smoking status

From: Difference in effects of cigarette smoking or alcohol consumption on serum non-high-density lipoprotein cholesterol levels is related to mitochondrial DNA 5178 C/A polymorphism in middle-aged Japanese men: a cross-sectional study

Genotype and number of cigarettes smoked daily Frequency OR (95% CI) Adjusted OR(95% CI) Adjusted OR(95% CI)
Normal levels of serum non-HDL cholesterol High levels of serum non-HDL cholesterol
  non-HDL cholesterol <160 mg/dl non-HDL cholesterol ≥160 mg/dl    
Mt5178C      
0 (never- or ex-smokers) 95 (66.9) 47 (33.1) 1 (reference) 1 (reference) 1 (reference)
1-20 46 (65.7) 24 (34.3) 1.055 (0.576-1.931) 1.079 (0.577-2.016) 0.955 (0.491-1.857)
>20 16 (59.3) 11 (40.7) 1.390 (0.598-3.230) 1.436 (0.591-3.492) 1.498 (0.596-3.765)
    P for trend = 0.495 P for trend = 0.403 P for trend = 0.619
Mt5178A      
0 (never- or ex-smokers) 71 (77.2) 21 (22.8) 1 (reference) 1 (reference) 1 (reference)
1-20 24 (60.0) 16 (40.0) 2.254 (1.015-5.007)* 3.035 (1.269-7.259)* 2.580 (1.027-6.481)*
>20 8 (34.8) 15 (65.2) 6.339 (2.364-17.00)*** 6.191 (2.258-16.97)*** 5.681 (2.022-15.96)**
    P for trend < 0.001 P for trend < 0.001 P for trend < 0.001
  non-HDL cholesterol <190 mg/dl non-HDL cholesterol ≥190 mg/dl    
Mt5178C      
0 (never- or ex-smokers) 126 (88.7) 16 (11.3) 1 (reference) 1 (reference) 1 (reference)
1-20 62 (88.6) 8 (11.4) 1.016 (0.413-2.503) 1.071 (0.427-2.686) 0.890 (0.334-2.376)
>20 22 (81.5) 5 (18.5) 1.790 (0.595-5.385) 1.943 (0.6.5-6.244) 2.210 (0.654-7.469)
    P for trend = 0.397 P for trend = 0.313 P for trend = 0.368
Mt5178A      
0 (never- or ex-smokers) 86 (93.5) 6 (6.5) 1 (reference) 1 (reference) 1 (reference)
1-20 35 (87.5) 2 (12.5) 2.048 (0.587-7.148) 2.420 (0.655-8.944) 2.815 (0.692-11.45)
>20 16 (69.6) 7 (30.4) 6.271 (1.862-21.11)** 6.081 (1.772-20.86)** 6.315 (1.715-23.25)*
    P for trend = 0.004 P for trend = 0.006 P for trend = 0.007
  1. OR adjusted for age and body mass index. OR adjusted for age, body mass index, habitual alcohol consumption, coffee consumption and antihypertensive medication. *P < 0.05, **P < 0.005, ***P < 0.001. CI, confidence interval; HDL, high-density lipoprotein; Mt5178C, mitochondrial DNA 5178 cytosine; Mt5178A, mitochondrial DNA 5178 adenosine; OR, odds ratio.