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Table 5 Odds ratios and 95% confidence intervals for high levels of serum non-HDL cholesterol by Mt5178 C/A genotype and drinking status

From: Difference in effects of cigarette smoking or alcohol consumption on serum non-high-density lipoprotein cholesterol levels is related to mitochondrial DNA 5178 C/A polymorphism in middle-aged Japanese men: a cross-sectional study

Genotype and alcohol consumption

Frequency

OR (95% CI)

Adjusted OR†(95% CI)

Adjusted OR‡(95% CI)

Normal levels of serum non-HDL cholesterol

High levels of serum non-HDL cholesterol

 

non-HDL cholesterol <160 mg/dl

non-HDL cholesterol ≥160 mg/dl

   

Mt5178C

     

Non- or ex-drinkers

22 (50.0)

22 (50.0)

1 (reference)

1 (reference)

1 (reference)

Occasional drinkers

55 (65.5)

29 (34.5)

0.527 (0.251-1.108)

0.430 (0.194-0.953)*

0.439 (0.190-1.016)

Daily drinkers

80 (72.1)

31 (27.9)

0.388 (0.188-0.798)*

0.308 (0.142-0.665)**

0.312 (0.139-0.698)**

   

P for trend = 0.012

P for trend = 0.005

P for trend = 0.005

Mt5178A

     

Non- or ex-drinkers

17 (81.0)

4 (19.0)

1 (reference)

1 (reference)

1 (reference)

Occasional drinkers

38 (63.3)

22 (36.7)

2.461 (0.734-8.244)

2.491 (0.720-8.619)

2.499 (0.649-9.618)

Daily drinkers

48 (64.9)

26 (35.1)

2.302 (0.701-7.561)

2.022 (0.595-6.875)

2.114 (0.583-7.665)

   

P for trend = 0.310

P for trend = 0.385

P for trend = 0.348

 

non-HDL cholesterol <190 mg/dl

non-HDL cholesterol ≥190 mg/dl

   

Mt5178C

     

Non- or ex-drinkers

36 (81.5)

8 (18.2)

1 (reference)

1 (reference)

1 (reference)

Occasional drinkers

74 (88.1)

10 (11.9)

0.608 (0.221-1.672)

0.627 (0.221-1.780)

0.858 (0.279-2.640)

Daily drinkers

100 (90.1)

11 (9.9)

0.495 (0.184-1.328)

0.408 (0.146-1.139)

0.330 (0.108-1.003)

   

P for trend = 0.181

P for trend = 0.140

P for trend = 0.123

Mt5178A

     

Non- or ex-drinkers

19 (90.5)

2 (9.5)

1 (reference)

1 (reference)

1 (reference)

Occasional drinkers

54 (90.0)

6 (10.0)

1.056 (0.196-5.684)

1.014 (0.176-5.853)

0.938 (0.154-5.714)

Daily drinkers

64 (86.5)

10 (13.5)

1.484 (0.299-7.368)

1.190 (0.230-6.156)

1.325 (0.219-7.996)

   

P for trend = 0.513

P for trend = 0.605

P for trend = 0.560

  1. †OR adjusted for age and body mass index. ‡OR adjusted for age, body mass index, cigarette smoking, coffee consumption and antihypertensive medication. *P < 0.05, **P < 0.005. CI, confidence interval; HDL, high-density lipoprotein; Mt5178C, mitochondrial DNA 5178 cytosine; Mt5178A, mitochondrial DNA 5178 adenosine; OR, odds ratio.
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Journal of Physiological Anthropology

ISSN: 1880-6805

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