Skip to main content

Table 1 Genotype and allele frequencies of LEP and LEPR SNPs according to BMI status, ethnicity, gender

From: Leptin and leptin receptor gene polymorphisms and their association with plasma leptin levels and obesity in a multi-ethnic Malaysian suburban population

SNP/Genotype/Allele Obesity status Ethnicity Gender
  Non-obese Obese Malay* Chinese Indian Male Female
LEP A19G        
AA 12 10 4 11 7 9 13
AG 88 79 52 73 42 63 104
GG 118 101 92 93 34 97 122
P 0.968   0.024   0.430
A 112 99 60 95 56 81 130
G 324 281 236 259 110 257 348
P 0.906   0.006   0.299
LEP G2548A        
GG 28 20 14 17 17 24 24
GA 81 89 59 67 44 62 108
AA 109 81 75 93 22 83 107
P 0.140   0.001   0.167
G 137 129 87 101 78 110 156
A 299 251 209 253 88 228 322
P 0.443   < 0.001   0.978
LEPR K109R        
KK 43 41 27 6 51 28 56
KR 75 76 63 60 28 62 89
RR 100 73 58 111 4 79 94
P 0308   < 0.001   0.169
K 161 158 117 72 130 118 201
R 275 222 179 282 36 220 277
P 0.174   < 0.001   0.040
LEPR Q223R        
QQ 14 14 7 4 17 6 22
QR 58 59 49 40 28 50 67
RR 146 117 92 133 38 113 150
P 0.524   < 0.001   0.084
Q 86 87 63 48 62 62 111
R 350 293 233 306 104 276 367
P 0.269   < 0.001   0.093
  1. All values by Chi-square test, significant at P < 0.05 and indicated in bold font.
  2. LEP, leptin; LEPR, leptin receptor; SNP, single nucleotide polymorphism. aMalay/Peninsular Bumiputra.