Leptin and leptin receptor gene polymorphisms and their association with plasma leptin levels and obesity in a multi-ethnic Malaysian suburban population

Table 1 Genotype and allele frequencies of LEP and LEPR SNPs according to BMI status, ethnicity, gender

SNP/Genotype/Allele	Obesity status		Ethnicity			Gender
	Non-obese	Obese	Malay*	Chinese	Indian	Male	Female
*LEP* A19G
AA	12	10	4	11	7	9	13
AG	88	79	52	73	42	63	104
GG	118	101	92	93	34	97	122
P	0.968			0.024		0.430
A	112	99	60	95	56	81	130
G	324	281	236	259	110	257	348
P	0.906			0.006		0.299
*LEP* G2548A
GG	28	20	14	17	17	24	24
GA	81	89	59	67	44	62	108
AA	109	81	75	93	22	83	107
P	0.140			0.001		0.167
G	137	129	87	101	78	110	156
A	299	251	209	253	88	228	322
P	0.443			< 0.001		0.978
*LEPR* K109R
KK	43	41	27	6	51	28	56
KR	75	76	63	60	28	62	89
RR	100	73	58	111	4	79	94
P	0308			< 0.001		0.169
K	161	158	117	72	130	118	201
R	275	222	179	282	36	220	277
P	0.174			< 0.001		0.040
*LEPR* Q223R
QQ	14	14	7	4	17	6	22
QR	58	59	49	40	28	50	67
RR	146	117	92	133	38	113	150
P	0.524			< 0.001		0.084
Q	86	87	63	48	62	62	111
R	350	293	233	306	104	276	367
P	0.269			< 0.001		0.093

All values by Chi-square test, significant at P < 0.05 and indicated in bold font.
LEP, leptin; LEPR, leptin receptor; SNP, single nucleotide polymorphism. ^aMalay/Peninsular Bumiputra.

ISSN: 1880-6805