|
SNP/Genotype/Allele
|
Obesity status
|
Ethnicity
|
Gender
|
|---|
| |
Non-obese
|
Obese
|
Malay*
|
Chinese
|
Indian
|
Male
|
Female
|
|---|
|
LEP
A19G
| | | | | | | |
|
AA
|
12
|
10
|
4
|
11
|
7
|
9
|
13
|
|
AG
|
88
|
79
|
52
|
73
|
42
|
63
|
104
|
|
GG
|
118
|
101
|
92
|
93
|
34
|
97
|
122
|
|
P
|
0.968
| |
0.024
| |
0.430
|
|
A
|
112
|
99
|
60
|
95
|
56
|
81
|
130
|
|
G
|
324
|
281
|
236
|
259
|
110
|
257
|
348
|
|
P
|
0.906
| |
0.006
| |
0.299
|
|
LEP
G2548A
| | | | | | | |
|
GG
|
28
|
20
|
14
|
17
|
17
|
24
|
24
|
|
GA
|
81
|
89
|
59
|
67
|
44
|
62
|
108
|
|
AA
|
109
|
81
|
75
|
93
|
22
|
83
|
107
|
|
P
|
0.140
| |
0.001
| |
0.167
|
|
G
|
137
|
129
|
87
|
101
|
78
|
110
|
156
|
|
A
|
299
|
251
|
209
|
253
|
88
|
228
|
322
|
|
P
|
0.443
| |
< 0.001
| |
0.978
|
|
LEPR
K109R
| | | | | | | |
|
KK
|
43
|
41
|
27
|
6
|
51
|
28
|
56
|
|
KR
|
75
|
76
|
63
|
60
|
28
|
62
|
89
|
|
RR
|
100
|
73
|
58
|
111
|
4
|
79
|
94
|
|
P
|
0308
| |
< 0.001
| |
0.169
|
|
K
|
161
|
158
|
117
|
72
|
130
|
118
|
201
|
|
R
|
275
|
222
|
179
|
282
|
36
|
220
|
277
|
|
P
|
0.174
| |
< 0.001
| |
0.040
|
|
LEPR
Q223R
| | | | | | | |
|
QQ
|
14
|
14
|
7
|
4
|
17
|
6
|
22
|
|
QR
|
58
|
59
|
49
|
40
|
28
|
50
|
67
|
|
RR
|
146
|
117
|
92
|
133
|
38
|
113
|
150
|
|
P
|
0.524
| |
< 0.001
| |
0.084
|
|
Q
|
86
|
87
|
63
|
48
|
62
|
62
|
111
|
|
R
|
350
|
293
|
233
|
306
|
104
|
276
|
367
|
|
P
|
0.269
| |
< 0.001
| |
0.093
|
- All values by Chi-square test, significant at P < 0.05 and indicated in bold font.
- LEP, leptin; LEPR, leptin receptor; SNP, single nucleotide polymorphism. aMalay/Peninsular Bumiputra.
