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Table 2 Means of anthropometric and clinical variables according to LEP and LEPR SNPs genotypes and alleles

From: Leptin and leptin receptor gene polymorphisms and their association with plasma leptin levels and obesity in a multi-ethnic Malaysian suburban population

Anthropometric and clinical variables Mean ± SEM
LEP A19G   LEP G2548A   LEPR K109R   LEPR Q223R  
Alleles   Alleles   Alleles   Alleles  
  A G P G A P K R P Q R P
SBP (mmHg) 137.56 ± 1.47 140.05 ± 0.87 0.146 139.75 ± 1.32 139.24 ± 0.91 0.751 141.85 ± 1.21 137.84 ± 0.96 0.010 144.00 ± 1.62 138.17 ± 0.84 0.001
DBP (mmHg) 80.53 ± 0.74 81.27 ± 0.43 0.387 81.79 ± 0.66 80.74 ± 0.45 0.187 82.06 ± 0.60 80.45 ± 0.48 0.040 82.08 ± 0.81 80.81 ± 0.42 0.166
Pulse rate (bpm) 73.32 ± 0.90 74.32 ± 0.53 0.335 73.74 ± 0.80 74.22 ± 0.56 0.621 75.14 ± 0.74 73.88 ± 0.59 0.065 74.98 ± 0.99 73.82 ± 0.51 0.298
WC (cm) 90.52 ± 0.80 91.16 ± 0.47 0.488 91.10 ± 0.71 90.95 ± 0.50 0.862 92.95 ± 0.65 89.74 ± 0.52 < 0.001 92.43 ± 0.88 90.61 ± 0.46 0.068
WHR 0.89 ± 0.01 0.90 ± 0.003 0.231 0.90 ± 0.01 0.89 ± 0.003 0.341 0.90 ± 0.004 0.89 ± 0.004 0.039 0.89 ± 0.01 0.89 ± 0.003 0.973
Weight (kg) 69.29 ± 1.02 69.87 ± 0.60 0.625 70.11 ± 0.91 69.54 ± 0.63 0.611 71.42 ± 0.84 68.63 ± 0.67 0.010 70.95 ± 1.13 69.39 ± 0.58 0.223
BMI (kg/m2) 27.01 ± 0.35 27.22 ± 0.20 0.606 27.15 ± 0.31 27.18 ± 0.21 0.940 28.05 ± 0.28 26.60 ± 0.23 < 0.001 27.85 ± 0.38 26.99 ± 0.20 0.047
TBFa (%) 33.27 ± 0.48 33.31 ± 0.28 0.740 33.29 ± 0.43 33.31 ± 0.30 0.808 34.46 ± 0.39 32.56 ± 0.31 0.001 34.70 ± 0.53 32.93 ± 0.27 0.007
SFa (%) 27.36 ± 0.57 27.14 ± 0.33 0.904 27.14 ± 0.50 27.22 ± 0.35 0.913 28.72 ± 0.46 26.22 ± 0.37 < 0.001 28.87 ± 0.62 26.75 ± 0.32 0.005
VFLa (%) 11.79 ± 0.43 12.44 ± 0.25 0.188 12.16 ± 0.38 12.32 ± 0.27 0.636 13.06 ± 0.35 11.76 ± 0.28 0.006 12.92 ± 0.47 12.09 ± 0.25 0.076
RM (kcal) 1448.53 ± 18.06 1459.04 ± 10.63 0.617 1462.09 ± 16.09 1453.54 ± 11.16 0.663 1468.24 ± 14.83 1448.68 ± 11.82 0.308 1457.77 ± 19.95 1455.94 ± 10.31 0.935
SMa (%) 25.09 ± 0.28 25.05 ± 0.17 0.919 25.19 ± 0.25 24.99 ± 0.17 0.536 24.58 ± 0.23 25.36 ± 0.18 0.005 24.39 ± 0.31 25.24 ± 0.16 0.010
Leptina (ng/mL)b 33.48 ± 39.10 27.31 ± 35.29 0.325 32.40 ± 37.75 27.22 ± 35.63 0.053 32.34 ± 42.21 26.70 ± 31.96 0.010 30.06 ± 36.68 28.60 ± 36.34 0.058
  1. All values by univariate analysis of variance (General Linear Model) and adjusted for covariate ethnicity, significant at P < 0.05 and indicated in bold font. Values presented as adjusted mean ± SEM (estimated marginal means ± standard error of the mean).
  2. aValues were log transformed before analysis.
  3. bLeptin values were analyzed by Student’s t-test and presented as mean ± SD (standard deviation).
  4. BMI, body mass index; DBP, diastolic blood pressure; RM, resting metabolism; SBP, systolic blood pressure; TBF, total body fat; SF, subcutaneous fat; SM, skeletal muscle; VFL, visceral fat level; WC, waist circumference; WHR, Waist-to-hip ratio.