Leptin and leptin receptor gene polymorphisms and their association with plasma leptin levels and obesity in a multi-ethnic Malaysian suburban population

Fan, Sook-Ha; Say, Yee-How

doi:10.1186/1880-6805-33-15

Table 2 Means of anthropometric and clinical variables according to LEP and LEPR SNPs genotypes and alleles

From: Leptin and leptin receptor gene polymorphisms and their association with plasma leptin levels and obesity in a multi-ethnic Malaysian suburban population

Anthropometric and clinical variables	Mean ± SEM
	*LEP* A19G			*LEP* G2548A			*LEPR* K109R			*LEPR* Q223R
	Alleles			Alleles			Alleles			Alleles
	A	G	P	G	A	P	K	R	P	Q	R	P
SBP (mmHg)	137.56 ± 1.47	140.05 ± 0.87	0.146	139.75 ± 1.32	139.24 ± 0.91	0.751	141.85 ± 1.21	137.84 ± 0.96	0.010	144.00 ± 1.62	138.17 ± 0.84	0.001
DBP (mmHg)	80.53 ± 0.74	81.27 ± 0.43	0.387	81.79 ± 0.66	80.74 ± 0.45	0.187	82.06 ± 0.60	80.45 ± 0.48	0.040	82.08 ± 0.81	80.81 ± 0.42	0.166
Pulse rate (bpm)	73.32 ± 0.90	74.32 ± 0.53	0.335	73.74 ± 0.80	74.22 ± 0.56	0.621	75.14 ± 0.74	73.88 ± 0.59	0.065	74.98 ± 0.99	73.82 ± 0.51	0.298
WC (cm)	90.52 ± 0.80	91.16 ± 0.47	0.488	91.10 ± 0.71	90.95 ± 0.50	0.862	92.95 ± 0.65	89.74 ± 0.52	< 0.001	92.43 ± 0.88	90.61 ± 0.46	0.068
WHR	0.89 ± 0.01	0.90 ± 0.003	0.231	0.90 ± 0.01	0.89 ± 0.003	0.341	0.90 ± 0.004	0.89 ± 0.004	0.039	0.89 ± 0.01	0.89 ± 0.003	0.973
Weight (kg)	69.29 ± 1.02	69.87 ± 0.60	0.625	70.11 ± 0.91	69.54 ± 0.63	0.611	71.42 ± 0.84	68.63 ± 0.67	0.010	70.95 ± 1.13	69.39 ± 0.58	0.223
BMI (kg/m²)	27.01 ± 0.35	27.22 ± 0.20	0.606	27.15 ± 0.31	27.18 ± 0.21	0.940	28.05 ± 0.28	26.60 ± 0.23	< 0.001	27.85 ± 0.38	26.99 ± 0.20	0.047
TBF^a (%)	33.27 ± 0.48	33.31 ± 0.28	0.740	33.29 ± 0.43	33.31 ± 0.30	0.808	34.46 ± 0.39	32.56 ± 0.31	0.001	34.70 ± 0.53	32.93 ± 0.27	0.007
SF^a (%)	27.36 ± 0.57	27.14 ± 0.33	0.904	27.14 ± 0.50	27.22 ± 0.35	0.913	28.72 ± 0.46	26.22 ± 0.37	< 0.001	28.87 ± 0.62	26.75 ± 0.32	0.005
VFL^a (%)	11.79 ± 0.43	12.44 ± 0.25	0.188	12.16 ± 0.38	12.32 ± 0.27	0.636	13.06 ± 0.35	11.76 ± 0.28	0.006	12.92 ± 0.47	12.09 ± 0.25	0.076
RM (kcal)	1448.53 ± 18.06	1459.04 ± 10.63	0.617	1462.09 ± 16.09	1453.54 ± 11.16	0.663	1468.24 ± 14.83	1448.68 ± 11.82	0.308	1457.77 ± 19.95	1455.94 ± 10.31	0.935
SM^a (%)	25.09 ± 0.28	25.05 ± 0.17	0.919	25.19 ± 0.25	24.99 ± 0.17	0.536	24.58 ± 0.23	25.36 ± 0.18	0.005	24.39 ± 0.31	25.24 ± 0.16	0.010
Leptin^a (ng/mL)^b	33.48 ± 39.10	27.31 ± 35.29	0.325	32.40 ± 37.75	27.22 ± 35.63	0.053	32.34 ± 42.21	26.70 ± 31.96	0.010	30.06 ± 36.68	28.60 ± 36.34	0.058

All values by univariate analysis of variance (General Linear Model) and adjusted for covariate ethnicity, significant at P < 0.05 and indicated in bold font. Values presented as adjusted mean ± SEM (estimated marginal means ± standard error of the mean).
^aValues were log transformed before analysis.
^bLeptin values were analyzed by Student’s t-test and presented as mean ± SD (standard deviation).
BMI, body mass index; DBP, diastolic blood pressure; RM, resting metabolism; SBP, systolic blood pressure; TBF, total body fat; SF, subcutaneous fat; SM, skeletal muscle; VFL, visceral fat level; WC, waist circumference; WHR, Waist-to-hip ratio.

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ISSN: 1880-6805

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Journal of Physiological Anthropology

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