Leptin and leptin receptor gene polymorphisms and their association with plasma leptin levels and obesity in a multi-ethnic Malaysian suburban population

Table 3 The relationship between genotype combinations with blood pressures, anthropometric variables, and plasma leptin levels

Variable	Mean ± SD
	Subjects homozygous for all four SNPs^a	Subjects not homozygous for all four SNPs	P
	(n = 70)	(n = 338)	P
SBP (mmHg)	137.40 ± 19.83	139.83 ± 22.23	0.398
DBP (mmHg)	81.55 ± 10.51	80.98 ± 10.78	0.688
Pulse rate (bpm)	74.48 ± 12.60	73.98 ± 13.10	0.768
WC (cm)	90.94 ± 12.50	91.01 ± 11.51	0.966
HC (cm)	101.20 ± 11.09	102.13 ± 9.91	0.484
WHR	0.90 ± 0.08	0.89 ± 0.08	0.457
Height (cm)	161.11 ± 8.54	159.81 ± 9.39	0.283
Weight (kg)	70.38 ± 16.34	69.59 ± 14.63	0.686
BMI (kg/m²)	27.04 ± 5.57	27.20 ± 5.00	0.813
TBF^b (%)	31.92 ± 6.53	33.59 ± 6.98	0.131
SF^b (%)	25.25 ± 7.84	27.60 ± 8.20	0.045
VFL^b (%)	12.64 ± 6.87	12.19 ± 6.23	0.672
RM (kcal)	1,491.96 ± 282.82	1,448.95 ± 258.76	0.214
SM^b (%)	25.78 ± 3.82	24.91 ± 4.08	0.084
Leptin^b (ng/mL)	21.22 ± 27.96	30.50 ± 37.77	0.015

All values by Student’s t-test, significant at P < 0.05 and indicated in bold font.
^aSubjects with homozygous mutated genotypes for all four SNPs: GG for LEP A19G, AA for LEP G2548A, RR for both LEPR K109R and LEPR Q223R.
^bValues were log transformed before analysis.

ISSN: 1880-6805