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Table 2 Erythrocytic parameters by coffee consumption status and Mt5178 C/A genotype

From: Longevity-associated mitochondrial DNA 5178 C/A polymorphism modulates the effects of coffee consumption on erythrocytic parameters in Japanese men: an exploratory cross-sectional analysis

  Coffee consumption P for trend
  <1 cup per day 1 to 3 cups per day ≥4 cups per day  
Mt5178C N = 119 N = 123 N = 24  
Red blood cell count (104/μL) 480 ± 3 481 ± 3 468 ± 8 0.349
Red blood cell count (104/μL)a 484 ± 3 480 ± 3 463 ± 7* 0.022
Hematocrit (%) 43.9 ± 0.3 43.8 ± 0.3 43.1 ± 0.6 0.426
Hematocrit (%)a 43.9 ± 0.3 43.5 ± 0.3 42.6 ± 0.6 0.059
Hemoglobin (g/dL) 15.0 ± 0.1 14.9 ± 0.1 14.8 ± 0.2 0.329
Hemoglobin (g/dL)a 15.0 ± 0.1 14.8 ± 0.1 14.6 ± 0.2 0.035
Mean corpuscular volume (fl) 91.4 ± 0.4 91.2 ± 0.4 92.2 ± 0.9 0.681
Mean corpuscular volume (fl)a 90.8 ± 0.4 90.9 ± 0.4 92.1 ± 0.8 0.275
Mt5178A N = 62 N = 87 N = 21  
Red blood cell count (104/μL) 490 ± 5 485 ± 4 487 ± 9 0.615
Red blood cell count (104/μL)a 491 ± 5 483 ± 5 487 ± 9 0.485
Hematocrit (%) 44.2 ± 0.4 44.2 ± 0.3 44.6 ± 0.6 0.668
Hematocrit (%)a 44.4 ± 0.4 44.1 ± 0.3 44.4 ± 0.6 0.889
Hemoglobin (g/dL) 15.1 ± 0.1 15.1 ± 0.1 15.2 ± 0.2 0.758
Hemoglobin (g/dL)a 15.2 ± 0.1 15.0 ± 0.1 15.1 ± 0.2 0.711
Mean corpuscular volume (fl) 90.6 ± 0.6 91.5 ± 0.5 91.7 ± 1.0 0.247
Mean corpuscular volume (fl)a 90.8 ± 0.6 91.5 ± 0.5 91.4 ± 0.9 0.451
  1. aMean ± standard error adjusted for age, body mass index, alcohol consumption, habitual smoking and green tea consumption. Bonferroni correction for multiple comparison was applied. *P <0.05 versus <1 cup of coffee per day.