Longevity-associated mitochondrial DNA 5178 C/A polymorphism modulates the effects of coffee consumption on erythrocytic parameters in Japanese men: an exploratory cross-sectional analysis

Table 3 Odds ratios and 95% confidence intervals for anemia (hemoglobin <14 g/dL) by Mt5178 C/A genotype and coffee consumption

Genotype and coffee consumption	Frequency (%)		Odds ratio (95% confidence interval)	Adjusted odds ratio^a(95% confidence interval)
Genotype and coffee consumption	Normal hemoglobin level (hemoglobin ≥14 g/dL)	Anemia (hemoglobin <14 g/dL)	Odds ratio (95% confidence interval)	Adjusted odds ratio^a(95% confidence interval)
Mt5178C
<1 cup per day	99 (83.2)	20 (16.8)	1 (reference)	1 (reference)
1 to 3 cups per day	104 (84.6)	19 (15.4)	0.904 (0.456 to 1.795)	1.140 (0.527 to 2.467)
≥4 cups per day	17 (70.8)	7 (29.2)	2.038 (0.748 to 5.556)	3.771 (1.088 to 13.06)*
			P for trend = 0.386	P for trend = 0.078
Mt5178A
<1 cup per day	51 (82.3)	11 (17.7)	1 (reference)	1 (reference)
1 to 3 cups per day	80 (92.0)	7 (8.0)	0.406 (0.148 to 1.115)	0.383 (0.118 to 1.249)
≥4 cups per day	20 (95.2)	1 (4.8)	0.232 (0.028 to 1.915)	0.301 (0.029 to 3.094)
			P for trend = 0.049	P for trend = 0.137

^aOdds ratio adjusted for age, body mass index, habitual alcohol consumption, habitual smoking and green tea consumption. *P <0.05.

ISSN: 1880-6805