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Table 4 Carotid atherosclerosis in relation to hemoglobin A1c (HbA1c) levels in subjects not taking medication

From: Association between hemoglobin A1c and carotid atherosclerosis in rural community-dwelling elderly Japanese men

 

HbA 1c level quintiles

Q1 (low)

Q2

Q3

Q4

Q5 (high)

Total subject

 No. at risk

168

180

216

192

138

 No. of cases (percentage)

51 (30.4)

54 (30.0)

51 (23.6)

54 (28.1)

46 (33.3)

 Age-adjusted odds ratio (OR)

1.42 (0.89 to 2.26)

1.35 (0.85 to 2.13)

1.00

1.26 (0.80 to 1.98)

1.62 (1.00 to 2.63)

 Multivariable OR

1.36 (0.84 to 2.20)

1.44 (0.89 to 2.33)

1.00

1.30 (0.80 to 2.10)

1.58 (0.94 to 2.66)

Low body mass index (BMI)

 No. at risk

92

91

111

78

50

 No. of cases (percentage)

33 (35.9)

29 (31.9)

20 (18.0)

19 (24.4)

10 (20.0)

 Age-adjusted OR

2.40 (1.24 to 4.67)

2.04 (1.03 to 4.01)

1.00

1.42 (0.69 to 2.91)

1.13 (0.48 to 2.67)

 Multivariable OR

2.29 (1.12 to 4.66)

2.15 (1.05 to 4.39)

1.00

1.50 (0.67 to 3.33)

0.99 (0.39 to 2.53)

High BMI

 No. at risk

76

89

105

114

88

 No. of cases (percentage)

18 (23.7)

25 (28.1)

31 (29.5)

35 (30.7)

36 (40.9)

 Age-adjusted OR

0.80 (0.41 to 1.59)

0.93 (0.49 to 1.74)

1.00

1.07 (0.59 to 1.92)

1.66 (0.90 to 3.05)

 Multivariable OR

0.68 (0.33 to 1.41)

1.09 (0.55 to 2.16)

1.00

1.19 (0.64 to 2.21)

2.01 (1.04 to 3.90)

  1. Multivariable: adjusted further for age, systolic blood pressure, antihypertensive medication use, body mass index, smoking, alcohol intake, serum triglyceride (TG), serum HDL-cholesterol, serum aspartate aminotransferase (AST), and estimated glomerular filtration rate (GFR). Low BMI consists of BMI <23 kg/m2 and high BMI consists of BMI ≥23 kg/m2.