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Table 1 Clinical characteristics of study subjects by Mt5178 C/A genotype

From: Mitochondrial DNA 5178 C/A polymorphism modulates the effects of coffee consumption on elevated levels of serum liver enzymes in male Japanese health check-up examinees: an exploratory cross-sectional study

  Mt5178C Mt5178A P value
  N = 251 N = 170  
Age (years)a 54.5 (7.6) 53.6 (7.8) 0.245
BMI (kg/m2)a 23.1 (2.8) 23.5 (2.6) 0.103
SBP (mmHg)b 126.1 (16.0) 125.3 (13.9) 0.614
DBP (mmHg)b 73.9 (10.5) 73.5 (9.0) 0.628
AST (U/L)c 22 (18–27) 23 (19–27) 0.687
ALT (U/L)c 21 (15–32) 24 (18–35) 0.471
AST/ALT ratioc 1.037 (0.818–1.286) 0.918 (0.723–1.190) 0.004
GGT (U/L)c 42 (27–75) 47 (30–75) 0.427
TC (mg/dL)a 204.2 (31.5) 202.5 (31.9) 0.590
LDL-C (mg/dL)a 122.5 (30.4) 118.4 (31.7) 0.182
HDL-C (mg/dL)b 55.1 (13.6) 55.9 (15.7) 0.576
TG (mg/dL)c 112 (84–156) 113 (83–161) 0.378
Subjects with ≥140 mg/dL LDL-C (%)d 25.5 27.1 0.721
Subjects with ≥150 mg/dL TG (%)d 28.3 29.4 0.803
FPG (mg/dL)c 97 (92–105) 97 (91–103) 0.240
UA (mg/dL)a 5.93 (1.28) 5.98 (1.21) 0.686
Coffee consumption (<1 cup per day/1–2 cups per day/≥3 cups per day) (%)d 45.8/31.5/22.7 36.5/40.0/23.5 0.120
Green tea consumption (≤1 cup per day/2–3 cups per day/≥4 cups per day) (%)d 26.7/30.7/42.6 27.7/32.9/39.4 0.798
Alcohol consumption (non- or ex-/occasionally/daily drinkers) (%)d 17.9/34.3/47.8 12.9/40.0/47.1 0.285
Current smokers (%)d 58.6 58.2 0.946
Subjects under antihypertensive treatment (%)d 19.9 13.5 0.089
Subjects under antidiabetic treatment (%)d 7.2 7.7 0.855
  1. Age, BMI, SBP, DBP, TC levels, LDL-C levels, HDL-C levels, and UA levels are given as means (S.D.). AST levels, ALT levels, AST/ALT ratio, GGT levels, TG levels, and FPG levels are given as medians (interquartile range). All P values depict significance of differences between Mt5178C and Mt5178A
  2. BMI body mass index, SBP systolic blood pressure, DBP diastolic blood pressure, AST aspartate aminotransferase, ALT alanine aminotransferase, GGT gamma-glutamyl transpeptidase, TC total cholesterol, LDL-C low-density lipoprotein cholesterol, HDL-C high-density lipoprotein cholesterol, TG triglyceride, FPG fasting plasma glucose, UA uric acid
  3. aStudent’s t test
  4. bWelch’s t test
  5. cMann-Whitney test
  6. dChi-square test