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Table 1 Clinical characteristics of study subjects by Mt5178 C/A genotype

From: Mitochondrial DNA 5178 C/A polymorphism modulates the effects of coffee consumption on elevated levels of serum liver enzymes in male Japanese health check-up examinees: an exploratory cross-sectional study

 

Mt5178C

Mt5178A

P value

 

N = 251

N = 170

 

Age (years)a

54.5 (7.6)

53.6 (7.8)

0.245

BMI (kg/m2)a

23.1 (2.8)

23.5 (2.6)

0.103

SBP (mmHg)b

126.1 (16.0)

125.3 (13.9)

0.614

DBP (mmHg)b

73.9 (10.5)

73.5 (9.0)

0.628

AST (U/L)c

22 (18–27)

23 (19–27)

0.687

ALT (U/L)c

21 (15–32)

24 (18–35)

0.471

AST/ALT ratioc

1.037 (0.818–1.286)

0.918 (0.723–1.190)

0.004

GGT (U/L)c

42 (27–75)

47 (30–75)

0.427

TC (mg/dL)a

204.2 (31.5)

202.5 (31.9)

0.590

LDL-C (mg/dL)a

122.5 (30.4)

118.4 (31.7)

0.182

HDL-C (mg/dL)b

55.1 (13.6)

55.9 (15.7)

0.576

TG (mg/dL)c

112 (84–156)

113 (83–161)

0.378

Subjects with ≥140 mg/dL LDL-C (%)d

25.5

27.1

0.721

Subjects with ≥150 mg/dL TG (%)d

28.3

29.4

0.803

FPG (mg/dL)c

97 (92–105)

97 (91–103)

0.240

UA (mg/dL)a

5.93 (1.28)

5.98 (1.21)

0.686

Coffee consumption (<1 cup per day/1–2 cups per day/≥3 cups per day) (%)d

45.8/31.5/22.7

36.5/40.0/23.5

0.120

Green tea consumption (≤1 cup per day/2–3 cups per day/≥4 cups per day) (%)d

26.7/30.7/42.6

27.7/32.9/39.4

0.798

Alcohol consumption (non- or ex-/occasionally/daily drinkers) (%)d

17.9/34.3/47.8

12.9/40.0/47.1

0.285

Current smokers (%)d

58.6

58.2

0.946

Subjects under antihypertensive treatment (%)d

19.9

13.5

0.089

Subjects under antidiabetic treatment (%)d

7.2

7.7

0.855

  1. Age, BMI, SBP, DBP, TC levels, LDL-C levels, HDL-C levels, and UA levels are given as means (S.D.). AST levels, ALT levels, AST/ALT ratio, GGT levels, TG levels, and FPG levels are given as medians (interquartile range). All P values depict significance of differences between Mt5178C and Mt5178A
  2. BMI body mass index, SBP systolic blood pressure, DBP diastolic blood pressure, AST aspartate aminotransferase, ALT alanine aminotransferase, GGT gamma-glutamyl transpeptidase, TC total cholesterol, LDL-C low-density lipoprotein cholesterol, HDL-C high-density lipoprotein cholesterol, TG triglyceride, FPG fasting plasma glucose, UA uric acid
  3. aStudent’s t test
  4. bWelch’s t test
  5. cMann-Whitney test
  6. dChi-square test