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Table 3 Comparison of genotype distributions and allele frequencies for SNPs associated with HAPE risk under the dominant and recessive model in both groups, respectively

From: NR3C1 gene polymorphisms are associated with high-altitude pulmonary edema in Han Chinese

SNP

Genotype/allele

HAPE-p (n%)

HAPE-r (n%)

OR (95% CI)

χ 2

P

rs17287745

 Genotype

AA

98 (73.7)

81 (60.0)

   

AG

33 (24.8)

45 (33.3)

1.650 (0.964–2.823)

3.365

0.067

GG

2 (1.5)

9 (6.7)

5.444 (1.144–25.915)

5.558

0.018

 Allele

A

229 (86.1)

207 (76.7)

   

G

37 (13.9)

63 (23.3)

1.884 (1.204–2.946)

7.841

0.005

 Dominant model

AA

98 (73.7)

81 (60.0)

   

AG + GG

35 (26.3)

54 (40.0)

1.867 (1.113–3.131)

5.656

0.017

rs17209237

 Genotype

AA

95 (72)

83 (62.4)

   

AG

35 (26.5)

42 (31.6)

1.373 (0.803–2.349)

1.348

0.246

GG

2 (1.5)

8 (6.0)

4.578 (0.946–22.166)

4.222

0.040

 Allele

A

225 (85.2)

208 (78.2)

   

G

39 (14.8)

58 (21.8)

1.609 (1.028–2.517)

4.382

0.036

 Dominant model

AA

95 (72.0)

83 (62.4)

   

AG + GG

37 (28.0)

50 (37.6)

1.547 (0.922–2.594)

2.748

0.097

rs6191

 Genotype

CC

88 (66.7)

69 (51.9)

   

CA

38 (28.8)

53 (39.8)

1.779 (1.055–2.999)

4.709

0.03

AA

6 (4.5)

11 (8.3)

2.338 (0.824–6.638)

2.661

0.103

 Allele

C

214 (81.1)

191 (71.8)

   

A

50 (18.9)

75 (28.2)

1.681 (1.118–2.526)

6.299

0.012

 Dominant model

CC

88 (66.7)

69 (51.9)

   

CA + AA

44 (33.3)

64 (48.1)

1.855 (1.129–3.048)

5.999

0.014

rs17209251

 Genotype

AA

94 (72.3)

84 (62.7)

   

GA

34 (26.2)

42 (31.3)

1.382 (0.806–2.371)

1.388

0.239

GG

2 (1.5)

8 (6.0)

4.476 (0.925–21.671)

4.079

0.043

 Allele

A

222 (85.4)

210 (78.4)

   

G

38 (14.6)

58 (21.6)

1.614 (1.028–2.532)

4.380

0.036

 Dominant model

AA

94 (72.3)

84 (62.7)

   

GA + GG

36 (27.7)

50 (37.3)

1.554 (0.924–2.614)

2.781

0.095

rs6188

 Genotype

CC

112 (84.2)

98 (73.1)

   

CA

21 (15.8)

36 (26.9)

1.959 (1.072–3.579)

4.877

0.027

AA

0 (0.0)

0 (0.0)

   

 Allele

C

245 (92.1)

232 (86.6)

   

A

21 (7.9)

36 (13.4)

1.810 (1.027–3.193)

4.294

0.038

 Dominant model

CC

112 (84.2)

98 (73.1)

   

CA + AA

21 (15.8)

36 (26.9)

1.959 (1.072–3.579)

4.877

0.027

rs33388

 Genotype

TT

88 (66.7)

69 (51.1)

   

AT

38 (28.8)

54 (40)

1.812 (1.076–3.052)

5.047

0.025

AA

6 (4.5)

12 (8.9)

2.551 (0.911–7.141)

3.352

0.067

 Allele

T

214 (81.1)

192 (71.1)

   

A

50 (18.9)

78 (28.9)

1.739 (1.160–2.607)

7.251

0.007

 Dominant model

TT

88 (66.7)

69 (51.1)

   

AT+AA

44 (33.3)

66 (48.9)

1.913 (1.166–3.138)

6.666

0.010

rs2918417

 Genotype

CC

111 (84.1)

98 (73.1)

   

CT

21 (15.9)

36 (26.9)

1.942 (1.063–3.548)

4.741

0.029

TT

0 (0.0)

0 (0.0)

   

 Allele

C

243 (92.0)

232 (86.6)

   

T

21 (8.0)

36 (13.4)

1.796 (1.018–3.167)

4.172

0.041

 Dominant model

CC

111 (84.1)

98 (73.1)

   

CT + TT

21 (15.9)

36 (26.9)

1.942 (1.063–3.548)

4.741

0.029

rs6877893

 Genotype

AA

87 (68)

68 (51.1)

   

AG

35 (27.3)

54 (40.6)

1.974 (1.161–3.356)

6.385

0.012

GG

6 (4.7)

11 (8.3)

2.346 (0.826–6.663)

2.678

0.102

 Allele

A

209 (81.6)

190 (71.4)

   

G

47 (18.4)

76 (28.6)

1.779 (1.176–2.689)

7.553

0.006

 Dominant model

AA

87 (68.0)

68 (51.1)

   

AG + GG

41 (32.0)

65 (48.9)

2.028 (1.226–3.356)

7.670

0.006

rs1866388

 Genotype

AA

116 (87.9)

105 (78.4)

   

GA

16 (12.1)

29 (21.6)

2.002 (1.030–3.894)

4.288

0.038

GG

0 (0.0)

0 (0.0)

   

 Allele

A

248 (93.9)

239 (89.2)

   

G

16 (6.1)

29 (10.8)

1.881 (0.996–3.552)

3.892

0.049

 Dominant model

AA

116 (87.9)

105 (78.4)

   

AG + GG

16 (12.1)

29 (21.6)

2.002 (1.030–3.894)

4.288

0.038

rs41423247

 Genotype

GG

93 (69.9)

76 (56.3)

   

CG

36 (27.1)

49 (36.3)

1.666 (0.984–2.819)

3.636

0.057

CC

4 (3.0)

10 (7.4)

3.059 (0.923–10.142)

3.633

0.057

 Allele

G

222 (83.5)

201 (74.4)

   

C

44 (16.5)

69 (25.6)

1.732(1.134–2.645)

6.544

0.011

 Dominant model

GG

93 (69.9)

76 (56.3)

   

CG + CC

40 (30.1)

59 (43.7)

1.805 (1.091–2.985)

5.342

0.021

rs4634384

 Genotype

TT

87 (67.4)

68 (51.1)

   

CT

37 (28.7)

52 (39.1)

1.798 (1.061–3.047)

4.793

0.029

CC

5 (3.9)

13 (9.8)

3.326 (1.131–9.786)

5.206

0.023

 Allele

T

211 (81.8)

188 (70.7)

   

C

47 (18.2)

78 (29.3)

1.863 (1.234–2.812)

8.894

0.003

 Dominant model

TT

87 (67.4)

68 (51.1)

   

CT + CC

42 (32.6)

65 (48.9)

1.980 (1.200–3.269)

7.214

0.007

rs10052957

 Genotype

GG

112 (84.2)

99 (73.3)

   

GA

21 (15.8)

36 (26.7)

1.939 (1.062–3.542)

4.734

0.030

AA

0 (0.0)

0 (0.0)

   

 Allele

G

245 (92.1)

234 (86.7)

   

A

21 (7.9)

36 (13.3)

1.795 (1.018–3.165)

4.170

0.041

 Dominant model

GG

112 (84.2)

99 (73.3)

   

GA + AA

21 (15.8)

36 (26.7)

1.939 (1.062–3.542)

4.734

0.030

  1. Data are shown as odds ratio (OR), 95% confidence interval (CI), and P values comparing HAPE patients and control group
  2. P value in italics indicates statistical significance after comparisons
  3. HAPE-p high-altitude pulmonary edema patients, HAPE-r high-altitude pulmonary edema resistant (control)