From: NR3C1 gene polymorphisms are associated with high-altitude pulmonary edema in Han Chinese
SNP | Genotype/allele | HAPE-p (n%) | HAPE-r (n%) | OR (95% CI) | χ 2 | P |
---|---|---|---|---|---|---|
rs17287745 | ||||||
Genotype | AA | 98 (73.7) | 81 (60.0) | |||
AG | 33 (24.8) | 45 (33.3) | 1.650 (0.964–2.823) | 3.365 | 0.067 | |
GG | 2 (1.5) | 9 (6.7) | 5.444 (1.144–25.915) | 5.558 | 0.018 | |
Allele | A | 229 (86.1) | 207 (76.7) | |||
G | 37 (13.9) | 63 (23.3) | 1.884 (1.204–2.946) | 7.841 | 0.005 | |
Dominant model | AA | 98 (73.7) | 81 (60.0) | |||
AG + GG | 35 (26.3) | 54 (40.0) | 1.867 (1.113–3.131) | 5.656 | 0.017 | |
rs17209237 | ||||||
Genotype | AA | 95 (72) | 83 (62.4) | |||
AG | 35 (26.5) | 42 (31.6) | 1.373 (0.803–2.349) | 1.348 | 0.246 | |
GG | 2 (1.5) | 8 (6.0) | 4.578 (0.946–22.166) | 4.222 | 0.040 | |
Allele | A | 225 (85.2) | 208 (78.2) | |||
G | 39 (14.8) | 58 (21.8) | 1.609 (1.028–2.517) | 4.382 | 0.036 | |
Dominant model | AA | 95 (72.0) | 83 (62.4) | |||
AG + GG | 37 (28.0) | 50 (37.6) | 1.547 (0.922–2.594) | 2.748 | 0.097 | |
rs6191 | ||||||
Genotype | CC | 88 (66.7) | 69 (51.9) | |||
CA | 38 (28.8) | 53 (39.8) | 1.779 (1.055–2.999) | 4.709 | 0.03 | |
AA | 6 (4.5) | 11 (8.3) | 2.338 (0.824–6.638) | 2.661 | 0.103 | |
Allele | C | 214 (81.1) | 191 (71.8) | |||
A | 50 (18.9) | 75 (28.2) | 1.681 (1.118–2.526) | 6.299 | 0.012 | |
Dominant model | CC | 88 (66.7) | 69 (51.9) | |||
CA + AA | 44 (33.3) | 64 (48.1) | 1.855 (1.129–3.048) | 5.999 | 0.014 | |
rs17209251 | ||||||
Genotype | AA | 94 (72.3) | 84 (62.7) | |||
GA | 34 (26.2) | 42 (31.3) | 1.382 (0.806–2.371) | 1.388 | 0.239 | |
GG | 2 (1.5) | 8 (6.0) | 4.476 (0.925–21.671) | 4.079 | 0.043 | |
Allele | A | 222 (85.4) | 210 (78.4) | |||
G | 38 (14.6) | 58 (21.6) | 1.614 (1.028–2.532) | 4.380 | 0.036 | |
Dominant model | AA | 94 (72.3) | 84 (62.7) | |||
GA + GG | 36 (27.7) | 50 (37.3) | 1.554 (0.924–2.614) | 2.781 | 0.095 | |
rs6188 | ||||||
Genotype | CC | 112 (84.2) | 98 (73.1) | |||
CA | 21 (15.8) | 36 (26.9) | 1.959 (1.072–3.579) | 4.877 | 0.027 | |
AA | 0 (0.0) | 0 (0.0) | ||||
Allele | C | 245 (92.1) | 232 (86.6) | |||
A | 21 (7.9) | 36 (13.4) | 1.810 (1.027–3.193) | 4.294 | 0.038 | |
Dominant model | CC | 112 (84.2) | 98 (73.1) | |||
CA + AA | 21 (15.8) | 36 (26.9) | 1.959 (1.072–3.579) | 4.877 | 0.027 | |
rs33388 | ||||||
Genotype | TT | 88 (66.7) | 69 (51.1) | |||
AT | 38 (28.8) | 54 (40) | 1.812 (1.076–3.052) | 5.047 | 0.025 | |
AA | 6 (4.5) | 12 (8.9) | 2.551 (0.911–7.141) | 3.352 | 0.067 | |
Allele | T | 214 (81.1) | 192 (71.1) | |||
A | 50 (18.9) | 78 (28.9) | 1.739 (1.160–2.607) | 7.251 | 0.007 | |
Dominant model | TT | 88 (66.7) | 69 (51.1) | |||
AT+AA | 44 (33.3) | 66 (48.9) | 1.913 (1.166–3.138) | 6.666 | 0.010 | |
rs2918417 | ||||||
Genotype | CC | 111 (84.1) | 98 (73.1) | |||
CT | 21 (15.9) | 36 (26.9) | 1.942 (1.063–3.548) | 4.741 | 0.029 | |
TT | 0 (0.0) | 0 (0.0) | ||||
Allele | C | 243 (92.0) | 232 (86.6) | |||
T | 21 (8.0) | 36 (13.4) | 1.796 (1.018–3.167) | 4.172 | 0.041 | |
Dominant model | CC | 111 (84.1) | 98 (73.1) | |||
CT + TT | 21 (15.9) | 36 (26.9) | 1.942 (1.063–3.548) | 4.741 | 0.029 | |
rs6877893 | ||||||
Genotype | AA | 87 (68) | 68 (51.1) | |||
AG | 35 (27.3) | 54 (40.6) | 1.974 (1.161–3.356) | 6.385 | 0.012 | |
GG | 6 (4.7) | 11 (8.3) | 2.346 (0.826–6.663) | 2.678 | 0.102 | |
Allele | A | 209 (81.6) | 190 (71.4) | |||
G | 47 (18.4) | 76 (28.6) | 1.779 (1.176–2.689) | 7.553 | 0.006 | |
Dominant model | AA | 87 (68.0) | 68 (51.1) | |||
AG + GG | 41 (32.0) | 65 (48.9) | 2.028 (1.226–3.356) | 7.670 | 0.006 | |
rs1866388 | ||||||
Genotype | AA | 116 (87.9) | 105 (78.4) | |||
GA | 16 (12.1) | 29 (21.6) | 2.002 (1.030–3.894) | 4.288 | 0.038 | |
GG | 0 (0.0) | 0 (0.0) | ||||
Allele | A | 248 (93.9) | 239 (89.2) | |||
G | 16 (6.1) | 29 (10.8) | 1.881 (0.996–3.552) | 3.892 | 0.049 | |
Dominant model | AA | 116 (87.9) | 105 (78.4) | |||
AG + GG | 16 (12.1) | 29 (21.6) | 2.002 (1.030–3.894) | 4.288 | 0.038 | |
rs41423247 | ||||||
Genotype | GG | 93 (69.9) | 76 (56.3) | |||
CG | 36 (27.1) | 49 (36.3) | 1.666 (0.984–2.819) | 3.636 | 0.057 | |
CC | 4 (3.0) | 10 (7.4) | 3.059 (0.923–10.142) | 3.633 | 0.057 | |
Allele | G | 222 (83.5) | 201 (74.4) | |||
C | 44 (16.5) | 69 (25.6) | 1.732(1.134–2.645) | 6.544 | 0.011 | |
Dominant model | GG | 93 (69.9) | 76 (56.3) | |||
CG + CC | 40 (30.1) | 59 (43.7) | 1.805 (1.091–2.985) | 5.342 | 0.021 | |
rs4634384 | ||||||
Genotype | TT | 87 (67.4) | 68 (51.1) | |||
CT | 37 (28.7) | 52 (39.1) | 1.798 (1.061–3.047) | 4.793 | 0.029 | |
CC | 5 (3.9) | 13 (9.8) | 3.326 (1.131–9.786) | 5.206 | 0.023 | |
Allele | T | 211 (81.8) | 188 (70.7) | |||
C | 47 (18.2) | 78 (29.3) | 1.863 (1.234–2.812) | 8.894 | 0.003 | |
Dominant model | TT | 87 (67.4) | 68 (51.1) | |||
CT + CC | 42 (32.6) | 65 (48.9) | 1.980 (1.200–3.269) | 7.214 | 0.007 | |
rs10052957 | ||||||
Genotype | GG | 112 (84.2) | 99 (73.3) | |||
GA | 21 (15.8) | 36 (26.7) | 1.939 (1.062–3.542) | 4.734 | 0.030 | |
AA | 0 (0.0) | 0 (0.0) | ||||
Allele | G | 245 (92.1) | 234 (86.7) | |||
A | 21 (7.9) | 36 (13.3) | 1.795 (1.018–3.165) | 4.170 | 0.041 | |
Dominant model | GG | 112 (84.2) | 99 (73.3) | |||
GA + AA | 21 (15.8) | 36 (26.7) | 1.939 (1.062–3.542) | 4.734 | 0.030 |