Skip to main content

Table 2 Simple and multiple linear regression models for blood urea nitrogen, creatinine, and estimated glomerular filtration rate by Mt5178 C/A genotype

From: Longevity-associated mitochondrial DNA 5178 C/A polymorphism modifies effect of aging on renal function in male Japanese health checkup examinees: an exploratory cross-sectional study

Simple linear regression model
  Blood urea nitrogen Creatinine Estimated glomerular filtration rate  
Regression coefficient Standard error P value Regression coefficient Standard error P value Regression coefficient Standard error P value  
 Mt5178C
  Age 0.806 0.329 0.015 0.018 0.010 0.087 − 5.900 1.159 < 0.001  
  Body mass index − 0.084 0.085 0.324 0.003 0.003 0.241 − 0.274 0.312 0.381  
  Smoking status − 0.623 0.338 0.067 − 0.004 0.011 0.705 1.113 1.244 0.372  
  Alcohol consumption − 0.029 0.315 0.925 − 0.004 0.010 0.705 0.791 1.150 0.492  
  Green tea consumption 0.216 0.217 0.320 0.004 0.007 0.546 − 1.281 0.790 0.106  
  Antihypertensive medication − 0.313 0.598 0.601 0.015 0.019 0.433 − 2.565 2.186 0.242  
 Mt5178A
  Age 1.229 0.342 < 0.001 − 0.001 0.012 0.956 − 3.877 1.273 0.003  
  Body mass index 0.034 0.103 0.745 0.002 0.003 0.549 − 0.224 0.379 0.555  
  Smoking status − 0.582 0.360 0.109 − 0.021 0.012 0.075 2.694 1.320 0.043  
  Alcohol consumption − 0.180 0.383 0.639 − 0.025 0.012 0.048 3.996 1.376 0.004  
  Green tea consumption − 0.014 0.253 0.957 0.007 0.008 0.400 − 1.798 0.922 0.053  
  Antihypertensive medication 0.146 0.793 0.855 0.041 0.026 0.117 − 5.445 2.887 0.061  
Multiple linear regression model
  Blood urea nitrogen Creatinine Estimated glomerular filtration rate  
Partial regression coefficient Standard error P value Partial regression coefficient Standard error P value Partial regression coefficient Standard error P value Variance inflation factor
 Mt5178C
  Age 0.722 0.346 0.038 0.018 0.011 0.109 − 5.811 1.226 < 0.001 1.108
  Body mass index − 0.085 0.086 0.321 0.004 0.003 0.206 − 0.368 0.304 0.228 1.034
  Smoking habit − 0.612 0.346 0.079 0.001 0.011 0.951 0.036 1.226 0.976 1.059
  Alcohol consumption 0.056 0.321 0.863 − 0.007 0.010 0.528 1.126 1.138 0.323 1.069
  Green tea consumption 0.136 0.222 0.542 0.000 0.004 0.951 − 0.296 0.786 0.707 1.073
  Antihypertensive medication − 0.733 0.623 0.241 0.010 0.020 0.615 − 0.916 2.206 0.678 1.109
 Mt5178A
  Age 1.370 0.375 < 0.001 − 0.012 0.013 0.308 − 2.653 1.359 0.053 1.194
  Body mass index 0.052 0.101 0.605 0.002 0.003 0.596 − 0.284 0.365 0.438 1.027
  Smoking habit − 0.414 0.357 0.248 − 0.020 0.012 0.096 1.863 1.293 0.152 1.036
  Alcohol consumption − 0.126 0.378 0.739 − 0.025 0.013 0.052 3.580 1.369 0.010 1.042
  Green tea consumption − 0.306 0.259 0.240 0.005 0.009 0.603 − 0.679 0.939 0.471 1.122
  Antihypertensive medication − 0.756 0.805 0.349 0.043 0.027 0.115 − 3.146 2.916 0.282 1.106
  1. Variance inflation factor shows the value when all covariates are in the multiple linear regression model