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Table 2 Simple and multiple linear regression models for blood urea nitrogen, creatinine, and estimated glomerular filtration rate by Mt5178 C/A genotype

From: Longevity-associated mitochondrial DNA 5178 C/A polymorphism modifies effect of aging on renal function in male Japanese health checkup examinees: an exploratory cross-sectional study

Simple linear regression model

 

Blood urea nitrogen

Creatinine

Estimated glomerular filtration rate

 

Regression coefficient

Standard error

P value

Regression coefficient

Standard error

P value

Regression coefficient

Standard error

P value

 

 Mt5178C

  Age

0.806

0.329

0.015

0.018

0.010

0.087

− 5.900

1.159

< 0.001

 

  Body mass index

− 0.084

0.085

0.324

0.003

0.003

0.241

− 0.274

0.312

0.381

 

  Smoking status

− 0.623

0.338

0.067

− 0.004

0.011

0.705

1.113

1.244

0.372

 

  Alcohol consumption

− 0.029

0.315

0.925

− 0.004

0.010

0.705

0.791

1.150

0.492

 

  Green tea consumption

0.216

0.217

0.320

0.004

0.007

0.546

− 1.281

0.790

0.106

 

  Antihypertensive medication

− 0.313

0.598

0.601

0.015

0.019

0.433

− 2.565

2.186

0.242

 

 Mt5178A

  Age

1.229

0.342

< 0.001

− 0.001

0.012

0.956

− 3.877

1.273

0.003

 

  Body mass index

0.034

0.103

0.745

0.002

0.003

0.549

− 0.224

0.379

0.555

 

  Smoking status

− 0.582

0.360

0.109

− 0.021

0.012

0.075

2.694

1.320

0.043

 

  Alcohol consumption

− 0.180

0.383

0.639

− 0.025

0.012

0.048

3.996

1.376

0.004

 

  Green tea consumption

− 0.014

0.253

0.957

0.007

0.008

0.400

− 1.798

0.922

0.053

 

  Antihypertensive medication

0.146

0.793

0.855

0.041

0.026

0.117

− 5.445

2.887

0.061

 

Multiple linear regression model

 

Blood urea nitrogen

Creatinine

Estimated glomerular filtration rate

 

Partial regression coefficient

Standard error

P value

Partial regression coefficient

Standard error

P value

Partial regression coefficient

Standard error

P value

Variance inflation factor

 Mt5178C

  Age

0.722

0.346

0.038

0.018

0.011

0.109

− 5.811

1.226

< 0.001

1.108

  Body mass index

− 0.085

0.086

0.321

0.004

0.003

0.206

− 0.368

0.304

0.228

1.034

  Smoking habit

− 0.612

0.346

0.079

0.001

0.011

0.951

0.036

1.226

0.976

1.059

  Alcohol consumption

0.056

0.321

0.863

− 0.007

0.010

0.528

1.126

1.138

0.323

1.069

  Green tea consumption

0.136

0.222

0.542

0.000

0.004

0.951

− 0.296

0.786

0.707

1.073

  Antihypertensive medication

− 0.733

0.623

0.241

0.010

0.020

0.615

− 0.916

2.206

0.678

1.109

 Mt5178A

  Age

1.370

0.375

< 0.001

− 0.012

0.013

0.308

− 2.653

1.359

0.053

1.194

  Body mass index

0.052

0.101

0.605

0.002

0.003

0.596

− 0.284

0.365

0.438

1.027

  Smoking habit

− 0.414

0.357

0.248

− 0.020

0.012

0.096

1.863

1.293

0.152

1.036

  Alcohol consumption

− 0.126

0.378

0.739

− 0.025

0.013

0.052

3.580

1.369

0.010

1.042

  Green tea consumption

− 0.306

0.259

0.240

0.005

0.009

0.603

− 0.679

0.939

0.471

1.122

  Antihypertensive medication

− 0.756

0.805

0.349

0.043

0.027

0.115

− 3.146

2.916

0.282

1.106

  1. Variance inflation factor shows the value when all covariates are in the multiple linear regression model