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Table 3 Odds ratios (ORs) and 95% confidence intervals (CIs) for reduced eGFR (< 90 mL/min/1.73 m2 or < 75 mL/min/1.73 m2) by Mt5178 C/A genotype and age group

From: Longevity-associated mitochondrial DNA 5178 C/A polymorphism modifies effect of aging on renal function in male Japanese health checkup examinees: an exploratory cross-sectional study

Genotype and age group

Renal function

OR (95% CI)

Adjusted OR† (95% CI)

 

eGFR ≥ 90 mL/min/1.73 m2

eGFR < 90 mL/min/1.73 m2

  

Mt5178C

N (%)

N (%)

  

 < 50 years

22 (34.9)

41 (65.1)

1 (reference)

1 (reference)

 50–59 years

18 (14.8)

104 (85.2)

3.100 (1.509–6.370)**

3.086 (1.497–6.362)**

 ≥ 60 years

6 (9.7)

56 (90.3)

5.007 (1.863–13.45)**

4.206 (1.506–11.75)*

   

P for trend < 0.001

P for trend = 0.001

Mt5178A

N (%)

N (%)

  

 < 50 years

16 (29.6)

38 (70.4)

1 (reference)

1 (reference)

 50–59 years

18 (27.7)

47 (72.3)

1.099 (0.495–2.441)

1.053 (0.464–2.391)

 ≥ 60 years

5 (13.2)

33 (86.8)

2.779 (0.918–8.409)

2.070 (0.617–6.946)

   

P for trend = 0.090

P for trend = 0.179

 

eGFR ≥ 75 mL/min/1.73 m2

eGFR < 75 mL/min/1.73 m2

  

Mt5178C

N (%)

N (%)

  

 < 50 years

53 (84.1)

10 (15.9)

1 (reference)

1 (reference)

 50–59 years

70 (57.4)

52 (42.6)

3.937 (1.832–8.461)***

3.955 (1.821–8.591)***

 ≥ 60 years

24 (38.7)

38 (61.3)

8.391 (3.596–19.58)***

7.961 (3.261–19.43)***

   

P for trend < 0.001

P for trend < 0.001

Mt5178A

N (%)

N (%)

  

 < 50 years

43 (79.6)

11 (20.4)

1 (reference)

1 (reference)

 50–59 years

44 (67.7)

21 (32.3)

1.866 (0.804–4.330)

1.713 (0.712–4.126)

 ≥ 60 years

18 (47.4)

20 (52.6)

4.343 (1.733–10.89)**

3.667 (1.355–9.921)*

   

P for trend = 0.002

P for trend = 0.014

  1. †OR adjusted for smoking status and alcohol consumption
  2. *P < 0.05, **P < 0.005, ***P < 0.001