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Table 3 Odds ratios (ORs) and 95% confidence intervals (CIs) for reduced eGFR (< 90 mL/min/1.73 m2 or < 75 mL/min/1.73 m2) by Mt5178 C/A genotype and age group

From: Longevity-associated mitochondrial DNA 5178 C/A polymorphism modifies effect of aging on renal function in male Japanese health checkup examinees: an exploratory cross-sectional study

Genotype and age group Renal function OR (95% CI) Adjusted OR (95% CI)
  eGFR ≥ 90 mL/min/1.73 m2 eGFR < 90 mL/min/1.73 m2   
Mt5178C N (%) N (%)   
 < 50 years 22 (34.9) 41 (65.1) 1 (reference) 1 (reference)
 50–59 years 18 (14.8) 104 (85.2) 3.100 (1.509–6.370)** 3.086 (1.497–6.362)**
 ≥ 60 years 6 (9.7) 56 (90.3) 5.007 (1.863–13.45)** 4.206 (1.506–11.75)*
    P for trend < 0.001 P for trend = 0.001
Mt5178A N (%) N (%)   
 < 50 years 16 (29.6) 38 (70.4) 1 (reference) 1 (reference)
 50–59 years 18 (27.7) 47 (72.3) 1.099 (0.495–2.441) 1.053 (0.464–2.391)
 ≥ 60 years 5 (13.2) 33 (86.8) 2.779 (0.918–8.409) 2.070 (0.617–6.946)
    P for trend = 0.090 P for trend = 0.179
  eGFR ≥ 75 mL/min/1.73 m2 eGFR < 75 mL/min/1.73 m2   
Mt5178C N (%) N (%)   
 < 50 years 53 (84.1) 10 (15.9) 1 (reference) 1 (reference)
 50–59 years 70 (57.4) 52 (42.6) 3.937 (1.832–8.461)*** 3.955 (1.821–8.591)***
 ≥ 60 years 24 (38.7) 38 (61.3) 8.391 (3.596–19.58)*** 7.961 (3.261–19.43)***
    P for trend < 0.001 P for trend < 0.001
Mt5178A N (%) N (%)   
 < 50 years 43 (79.6) 11 (20.4) 1 (reference) 1 (reference)
 50–59 years 44 (67.7) 21 (32.3) 1.866 (0.804–4.330) 1.713 (0.712–4.126)
 ≥ 60 years 18 (47.4) 20 (52.6) 4.343 (1.733–10.89)** 3.667 (1.355–9.921)*
    P for trend = 0.002 P for trend = 0.014
  1. †OR adjusted for smoking status and alcohol consumption
  2. *P < 0.05, **P < 0.005, ***P < 0.001