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Table 4 Relationships between change in bone mineral parameters from baseline to follow-up and quartile groups of IGF-I levels

From: Associations between serum levels of insulin-like growth factor-I and bone mineral acquisition in pubertal children: a 3-year follow-up study in Hamamatsu, Japan

   

Mean

SD

P for ANOVA

P for ANCOVA

P for trend

Boys, N = 121

Change in TBLH BMC (g)

 

IGF-I Q1

396

112

< 0.001

0.005a

0.002a

 

IGF-I Q2

502

144

 

IGF-I Q3

514

158

 

IGF-I Q4

586

114

Change in TBLH aBMD (g/cm2)

 

IGF-I Q1

0.098

0.041

< 0.001

0.010b

0.012b

 

IGF-I Q2

0.138

0.062

 

IGF-I Q3

0.132

0.056

 

IGF-I Q4

0.155

0.048

Change in TB BMAD (g/cm3)

 

IGF-I Q1

− 0.009

0.005

< 0.001

nsb

nsb

 

IGF-I Q2

− 0.006

0.006

 

IGF-I Q3

− 0.006

0.007

 

IGF-I Q4

− 0.002

0.007

Girls, N = 133

Change in TBLH BMC (g)

 

IGF-I Q1

356

90

ns

nsa

nsa

 

IGF-I Q2

350

99

 

IGF-I Q3

352

106

 

IGF-I Q4

317

108

Change in TBLH aBMD (g/cm2)

 

IGF-I Q1

0.093

0.043

ns

nsb

nsb

 

IGF-I Q2

0.093

0.049

 

IGF-I Q3

0.100

0.053

 

IGF-I Q4

0.096

0.046

Change in TB BMAD (g/cm3)

 

IGF-I Q1

− 0.007

0.006

< 0.001

nsb

0.017b

 

IGF-I Q2

− 0.002

0.006

 

IGF-I Q3

0.000

0.006

 

IGF-I Q4

0.002

0.005

  1. IGF-I insulin-like growth factor-I, TBLH total body less head, BMC bone mineral content, N number, Q quartile, aBMD areal bone mineral density, TB total body, BMAD bone mineral apparent density as an estimate of volumetric bone mineral density, ns not significant, IGF-I Q1 the lowest quartile group of IGF-I levels, IGF-I Q4 the highest quartile group of IGF-I levels
  2. ANOVA and ANCOVA were performed to explore differences among quartiles
  3. Multiple linear regression analysis was performed for trend tests from the lowest to highest quartile of IGF-I
  4. P < 0.05 was considered statistically significant
  5. aAdjusted for 25-hydroxyvitamin D, sedentary behavior, pubic hair appearance, weight, and height at baseline
  6. bAdjusted for 25-hydroxyvitamin D, sedentary behavior, pubic hair appearance, and weight at baseline