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Table 4 Relationships between change in bone mineral parameters from baseline to follow-up and quartile groups of IGF-I levels

From: Associations between serum levels of insulin-like growth factor-I and bone mineral acquisition in pubertal children: a 3-year follow-up study in Hamamatsu, Japan

   MeanSDP for ANOVAP for ANCOVAP for trend
Boys, N = 121Change in TBLH BMC (g)
 IGF-I Q1396112< 0.0010.005a0.002a
 IGF-I Q2502144
 IGF-I Q3514158
 IGF-I Q4586114
Change in TBLH aBMD (g/cm2)
 IGF-I Q10.0980.041< 0.0010.010b0.012b
 IGF-I Q20.1380.062
 IGF-I Q30.1320.056
 IGF-I Q40.1550.048
Change in TB BMAD (g/cm3)
 IGF-I Q1− 0.0090.005< 0.001nsbnsb
 IGF-I Q2− 0.0060.006
 IGF-I Q3− 0.0060.007
 IGF-I Q4− 0.0020.007
Girls, N = 133Change in TBLH BMC (g)
 IGF-I Q135690nsnsansa
 IGF-I Q235099
 IGF-I Q3352106
 IGF-I Q4317108
Change in TBLH aBMD (g/cm2)
 IGF-I Q10.0930.043nsnsbnsb
 IGF-I Q20.0930.049
 IGF-I Q30.1000.053
 IGF-I Q40.0960.046
Change in TB BMAD (g/cm3)
 IGF-I Q1− 0.0070.006< 0.001nsb0.017b
 IGF-I Q2− 0.0020.006
 IGF-I Q30.0000.006
 IGF-I Q40.0020.005
  1. IGF-I insulin-like growth factor-I, TBLH total body less head, BMC bone mineral content, N number, Q quartile, aBMD areal bone mineral density, TB total body, BMAD bone mineral apparent density as an estimate of volumetric bone mineral density, ns not significant, IGF-I Q1 the lowest quartile group of IGF-I levels, IGF-I Q4 the highest quartile group of IGF-I levels
  2. ANOVA and ANCOVA were performed to explore differences among quartiles
  3. Multiple linear regression analysis was performed for trend tests from the lowest to highest quartile of IGF-I
  4. P < 0.05 was considered statistically significant
  5. aAdjusted for 25-hydroxyvitamin D, sedentary behavior, pubic hair appearance, weight, and height at baseline
  6. bAdjusted for 25-hydroxyvitamin D, sedentary behavior, pubic hair appearance, and weight at baseline