Table 1 Characteristics of study subjects with or without CIVD response

No. of subjects

10

84

Age, years

22.80 ± 0.44

22.24 ± 0.15

Height, cm

171.30 ± 2.30

171.83 ± 0.60

Weight, kg

62.22 ± 2.73

64.25 ± 1.20

Body mass index, kg/m²

21.24 ± 0.93

21.73 ± 0.38

Body temperature, °C

36.61 ± 0.13

36.45 ± 0.04

Minimum finger temperature during local cooling, °C

12.9 ± 2.0

10.3 ± 0.4

Mean finger temperature between 15 and 35 min, °C

16.6 ± 2.3

13.6 ± 0.4

Time for the first minimum blood flow, min^a

11.9 ± 0.3

11.7 ± 0.1

Neurogenic activity^b (Baseline)

0.35 ± 0.03

0.31 ± 0.01

Neurogenic activity^b (Phase 1)^c

0.24 ± 0.05

0.19 ± 0.01

Neurogenic activity^b (Phase 2)^c

0.14 ± 0.05

0.06 ± 0.01

Neurogenic activity^b (Phase 3)^c

0.20 ± 0.04

0.14 ± 0.01

eNO-dependent activity ^b (Baseline)

0.25 ± 0.03

0.25 ± 0.01

eNO-dependent activity ^b (Phase 1) ^c

0.27 ± 0.04

0.26 ± 0.01

eNO-dependent activity ^b (Phase 2) ^c

0.20 ± 0.04

0.14 ± 0.01

eNO-dependent activity ^b (Phase 3) ^c

0.20 ± 0.04

0.17 ± 0.01

eNO-independent activity ^b (Baseline)

0.24 ± 0.04

0.30 ± 0.01

eNO-independent activity ^b (Phase 1) ^c

0.38 ± 0.07

0.48 ± 0.02

eNO-independent activity ^b (Phase 2) ^c

0.58 ± 0.10

0.76 ± 0.02

eNO-independent activity ^b (Phase 3) ^c

0.45 ± 0.08

0.58 ± 0.02