Table 2 Summary of SNPs showing the significant association of CIVD with neurogenic and endothelial NO-independent activities according to two-way ANOVA
Genetic model | RefSNP ID | Positiona | Gene | Allele frequency | CADD score | Neurogenic | eNO-independent | ||
|---|---|---|---|---|---|---|---|---|---|
F | P | F | P | ||||||
Additive | rs17113836 | 5: 152,344,712 | LINC01470 | A: 0.72 T: 0.28 | 0.3 | 38.3 | 1.89 × 10−8 | 28.6 | 7.02 × 10−7 |
rs73619297 | 13: 110,967,247 | COL4A2 | G: 0.62 A: 0.38 | 0.7 | 21.1 | 3.24 × 10−8 | 13.2 | 9.36 × 10−6 | |
rs73619299 | 13: 110,967,456 | COL4A2 | C: 0.62 T: 0.38 | 2.8 | 21.1 | 3.24 × 10−8 | 13.2 | 9.36 × 10−6 | |
rs7321461 | 13: 110,967,990 | COL4A2 | A: 0.62 C: 0.38 | 0.1 | 21.1 | 3.24 × 10−8 | 13.2 | 9.36 × 10−6 | |
rs3832899 | 13: 110,968,318 | COL4A2 | T: 0.62 –: 0.38 | 1.5 | 21.1 | 3.24 × 10−8 | 13.2 | 9.36 × 10−6 | |
Dominant | rs931740 | 5: 35,222,040 | PRLR | T: 0.59 C: 0.41 | 5.3 | 39.9 | 1.03 × 10−8 | 24.6 | 3.29 × 10−6 |
rs10144241 | 14: 65,638,439 | 14q23.3 | C: 0.57 A: 0.43 | 11.3 | 35.6 | 4.78 × 10−8 | 22.1 | 9.39 × 10−6 | |
rs10133408 | 14: 65,638,443 | 14q23.3 | T: 0.57 G: 0.43 | 14.1 | 35.6 | 4.78 × 10−8 | 22.1 | 9.39 × 10−6 | |
rs11850650 | 14: 65,639,582 | 14q23.3 | T: 0.57 C: 0.43 | 7.4 | 35.6 | 4.78 × 10−8 | 22.1 | 9.39 × 10−6 | |
rs11158583 | 14: 65,641,686 | 14q23.3 | G: 0.57 C: 0.43 | 9.3 | 35.6 | 4.78 × 10−8 | 22.1 | 9.39 × 10−6 | |