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Table 2 Sex-specific odds ratio and 95% confidence interval for hypertension in relation to alkaline phosphatase levels

From: Association between alkaline phosphatase and hypertension in a rural Japanese population: The Nagasaki Islands study

 

ALP quartiles

1 SD increments in ALP

Log ALP

Q1 (low)

Q2

Q3

Q4 (high)

P for trend

Men

  Number at risk

205

215

207

208

   

  Number of cases (%)

118 (58)

134 (62)

134 (65)

128 (62)

   

  Age-adjusted OR

1.00

1.26 (0.85 to 1.88)

1.30 (0.87 to 1.95)

1.11 (0.75 to 1.66)

0.590

1.00 (0.87 to 1.16)

1.00 (0.62 to 1.59)

  Multivariable OR

1.00

1.30 (0.86 to 1.99)

1.29 (0.84 to 1.99)

1.16 (0.75 to 1.79)

0.535

0.98 (0.83 to 1.15)

0.95 (0.56 to 1.59)

Women

  Number at risk

465

458

467

456

   

  Number of cases (%)

186 (40)

271 (59)

273 (58)

305 (67)

   

  Age-adjusted OR

1.00

1.33 (0.98 to 1.78)

1.22 (0.91 to 1.64)

1.61 (1.19 to 2.17)

0.006

1.21 (1.09 to 1.35)

1.81 (1.26 to 2.60)

  Multivariable OR

1.00

1.29 (0.95 to 1.76)

1.14 (0.84 to 1.55)

1.49 (1.09 to 2.04)

0.041

1.17 (1.04 to 1.31)

1.57 (1.07 to 2.33)

  1. Multivariable odds ratio (OR) adjusted further for age, body mass index, smoking, alcohol intake, diabetes, thyroid disease, serum triglycerides, serum aspartate aminotransferase (AST) , serum γ-glutamyltranspeptidase (γ-GTP) and glomerular filtration rate. Hypertension defined as systolic blood pressure ≥140mmHg and/or diastolic blood pressure ≥90 mmHg and/or use of antihypertensive agents. Serum alkaline phosphatase (ALP) levels for quartiles were <194 U/l, 194 to 228 U/l, 229 to 275 U/l, and >275 U/l for men and <199 U/l, 199 to 240 U/l, 241 to 290 U/l, and >290 U/l for women.