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Table 2 Sex-specific odds ratio and 95% confidence interval for hypertension in relation to alkaline phosphatase levels

From: Association between alkaline phosphatase and hypertension in a rural Japanese population: The Nagasaki Islands study

  ALP quartiles 1 SD increments in ALP Log ALP
Q1 (low) Q2 Q3 Q4 (high) P for trend
Men
  Number at risk 205 215 207 208    
  Number of cases (%) 118 (58) 134 (62) 134 (65) 128 (62)    
  Age-adjusted OR 1.00 1.26 (0.85 to 1.88) 1.30 (0.87 to 1.95) 1.11 (0.75 to 1.66) 0.590 1.00 (0.87 to 1.16) 1.00 (0.62 to 1.59)
  Multivariable OR 1.00 1.30 (0.86 to 1.99) 1.29 (0.84 to 1.99) 1.16 (0.75 to 1.79) 0.535 0.98 (0.83 to 1.15) 0.95 (0.56 to 1.59)
Women
  Number at risk 465 458 467 456    
  Number of cases (%) 186 (40) 271 (59) 273 (58) 305 (67)    
  Age-adjusted OR 1.00 1.33 (0.98 to 1.78) 1.22 (0.91 to 1.64) 1.61 (1.19 to 2.17) 0.006 1.21 (1.09 to 1.35) 1.81 (1.26 to 2.60)
  Multivariable OR 1.00 1.29 (0.95 to 1.76) 1.14 (0.84 to 1.55) 1.49 (1.09 to 2.04) 0.041 1.17 (1.04 to 1.31) 1.57 (1.07 to 2.33)
  1. Multivariable odds ratio (OR) adjusted further for age, body mass index, smoking, alcohol intake, diabetes, thyroid disease, serum triglycerides, serum aspartate aminotransferase (AST) , serum γ-glutamyltranspeptidase (γ-GTP) and glomerular filtration rate. Hypertension defined as systolic blood pressure ≥140mmHg and/or diastolic blood pressure ≥90 mmHg and/or use of antihypertensive agents. Serum alkaline phosphatase (ALP) levels for quartiles were <194 U/l, 194 to 228 U/l, 229 to 275 U/l, and >275 U/l for men and <199 U/l, 199 to 240 U/l, 241 to 290 U/l, and >290 U/l for women.