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Table 3 Sex-specific data for hypertension in relation to alkaline phosphatase levels and drinking status

From: Association between alkaline phosphatase and hypertension in a rural Japanese population: The Nagasaki Islands study

  ALP quartiles 1 SD increments in ALP Log ALP
  Q1 (low) Q2 Q3 Q4 (high) P for trend
Nondrinker men
  Number at risk 77 100 112 115    
  Number of cases (%) 35 (45) 50 (50) 69 (62) 73 (63)    
  Age-adjusted OR 1.00 1.27 (0.69 to 2.34) 1.91 (1.04 to 3.48) 1.98 (1.09 to 3.62) 0.011 1.40 (1.10 to 1.79) 2.96 (1.33 to 6.58)
  Multivariable OR 1.00 1.37 (0.71 to 2.64) 1.96 (1.03 to 3.73) 2.23 (1.16 to 4.28) 0.009 1.46 (1.12 to 1.91) 3.32 (1.38 to 8.02)
Nondrinker women
  Number at risk 390 399 423 412    
  Number of cases (%) 162 (42) 238 (60) 250 (59) 277 (67)    
  Age-adjusted OR 1.00 1.34 (0.97 to 1.84) 1.27 (0.93 to 1.73) 1.64 (1.19 to 2.27) 0.006 1.22 (1.08 to 1.37) 1.84 (1.24 to 2.72)
  Multivariable OR 1.00 1.33 (0.96 to 1.85) 1.21 (0.87 to 1.67) 1.58 (1.12 to 2.21) 0.023 1.19 (1.05 to 1.35) 1.68 (1.11 to 2.55)
Drinker men  
  Number at risk 128 115 95 93    
  Number of cases (%) 83 (65) 84 (73) 65 (68) 55 (59)    
  Age-adjusted OR 1.00 1.53 (0.88 to 2.67) 1.14 (0.64 to 2.02) 0.76 (0.44 to 1.33) 0.295 0.82 (0.67 to 1.00) 0.59 (0.31 to 1.14)
  Multivariable OR 1.00 1.39 (0.78 to 2.50) 0.94 (0.51 to 1.73) 0.62 (0.34 to 1.14) 0.103 0.73 (0.58 to 0.91) 0.42 (0.20 to 0.89)
Drinker women
  Number at risk 75 59 44 44    
  Number of cases (%) 24 (32) 33 (56) 23 (52) 28 (64)    
  Age-adjusted OR 1.00 1.17 (0.52 to 2.66) 0.87 (0.36 to 2.12) 1.34 (0.54 to 3.28) 0.711 1.16 (0.87 to 1.55) 1.60 (0.58 to 4.41)
  Multivariable OR 1.00 0.89 (0.36 to 2.20) 0.70 (0.26 to 1.87) 1.14 (0.42 to 3.09) 0.953 1.01 (0.68 to 1.49) 1.03 (0.30 to 3.50)
  1. Data presented as odds ratio (95% confidence interval). Multivariable odds ratio (OR) adjusted further for age, body mass index, smoking, alcohol intake, diabetes, thyroid disease, serum triglycerides, serum aspartate aminotransferase (AST), serum γ-glutamyltranspeptidase (γ-GTP) and glomerular filtration rate. Hypertension defined as systolic blood pressure ≥140 mmHg and/or diastolic blood pressure ≥90 mmHg and/or use of antihypertensive agents. Serum alkaline phosphatase (ALP) levels for quartiles were <194 U/l, 194 to 228 U/l, 229 to 275 U/l, and >275 U/l for men and <199 U/l, 199 to 240 U/l, 241 to 290 U/l, and >290 U/l for women.