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Table 3 Sex-specific data for hypertension in relation to alkaline phosphatase levels and drinking status

From: Association between alkaline phosphatase and hypertension in a rural Japanese population: The Nagasaki Islands study

 

ALP quartiles

1 SD increments in ALP

Log ALP

 

Q1 (low)

Q2

Q3

Q4 (high)

P for trend

Nondrinker men

  Number at risk

77

100

112

115

   

  Number of cases (%)

35 (45)

50 (50)

69 (62)

73 (63)

   

  Age-adjusted OR

1.00

1.27 (0.69 to 2.34)

1.91 (1.04 to 3.48)

1.98 (1.09 to 3.62)

0.011

1.40 (1.10 to 1.79)

2.96 (1.33 to 6.58)

  Multivariable OR

1.00

1.37 (0.71 to 2.64)

1.96 (1.03 to 3.73)

2.23 (1.16 to 4.28)

0.009

1.46 (1.12 to 1.91)

3.32 (1.38 to 8.02)

Nondrinker women

  Number at risk

390

399

423

412

   

  Number of cases (%)

162 (42)

238 (60)

250 (59)

277 (67)

   

  Age-adjusted OR

1.00

1.34 (0.97 to 1.84)

1.27 (0.93 to 1.73)

1.64 (1.19 to 2.27)

0.006

1.22 (1.08 to 1.37)

1.84 (1.24 to 2.72)

  Multivariable OR

1.00

1.33 (0.96 to 1.85)

1.21 (0.87 to 1.67)

1.58 (1.12 to 2.21)

0.023

1.19 (1.05 to 1.35)

1.68 (1.11 to 2.55)

Drinker men

 

  Number at risk

128

115

95

93

   

  Number of cases (%)

83 (65)

84 (73)

65 (68)

55 (59)

   

  Age-adjusted OR

1.00

1.53 (0.88 to 2.67)

1.14 (0.64 to 2.02)

0.76 (0.44 to 1.33)

0.295

0.82 (0.67 to 1.00)

0.59 (0.31 to 1.14)

  Multivariable OR

1.00

1.39 (0.78 to 2.50)

0.94 (0.51 to 1.73)

0.62 (0.34 to 1.14)

0.103

0.73 (0.58 to 0.91)

0.42 (0.20 to 0.89)

Drinker women

  Number at risk

75

59

44

44

   

  Number of cases (%)

24 (32)

33 (56)

23 (52)

28 (64)

   

  Age-adjusted OR

1.00

1.17 (0.52 to 2.66)

0.87 (0.36 to 2.12)

1.34 (0.54 to 3.28)

0.711

1.16 (0.87 to 1.55)

1.60 (0.58 to 4.41)

  Multivariable OR

1.00

0.89 (0.36 to 2.20)

0.70 (0.26 to 1.87)

1.14 (0.42 to 3.09)

0.953

1.01 (0.68 to 1.49)

1.03 (0.30 to 3.50)

  1. Data presented as odds ratio (95% confidence interval). Multivariable odds ratio (OR) adjusted further for age, body mass index, smoking, alcohol intake, diabetes, thyroid disease, serum triglycerides, serum aspartate aminotransferase (AST), serum γ-glutamyltranspeptidase (γ-GTP) and glomerular filtration rate. Hypertension defined as systolic blood pressure ≥140 mmHg and/or diastolic blood pressure ≥90 mmHg and/or use of antihypertensive agents. Serum alkaline phosphatase (ALP) levels for quartiles were <194 U/l, 194 to 228 U/l, 229 to 275 U/l, and >275 U/l for men and <199 U/l, 199 to 240 U/l, 241 to 290 U/l, and >290 U/l for women.