An adaptive variant of TRIB2, rs1057001, is associated with higher expression levels of thermogenic genes in human subcutaneous and visceral adipose tissues

Table 2 Transcription levels of the tested genes in the TRIB2 genotype groups

Gene symbol	Mean (SD) transcription level in subcutaneous adipose tissues		Ratio	P	Mean (SD) transcription level in visceral adipose tissues		Ratio	P
Gene symbol	AA	AT + TT	Ratio	P	AA	AT + TT	Ratio	P
CIDEA	0.4474 (0.1986)	0.2999 (0.2094)	1.45	0.016	0.2962 (0.2511)	0.1897 (0.1572)	1.55	0.095
DIO2	0.0012 (0.0017)	0.0005 (0.0003)	2.51	0.036	0.0012 (0.0009)	0.0006 (0.0007)	2.00	0.015
PPARGC1A	0.0023 (0.0015)	0.0012 (0.0005)	1.80	0.002	0.0017 (0.0009)	0.0012 (0.0009)	1.51	0.034
PRDM16	0.0074 (0.0058)	0.0041 (0.0033)	1.73	0.021	0.0028 (0.0022)	0.0018 (0.0014)	1.58	0.084
ACC	0.0054 (0.0038)	0.0082 (0.0061)	0.65	0.065	0.0045 (0.003)	0.006 (0.0034)	0.75	0.112
DGAT1	0.0405 (0.024)	0.044 (0.0227)	0.96	0.61	0.0935 (0.0371)	0.1052 (0.0652)	0.88	0.440
FASN	0.2635 (0.1727)	0.4259 (0.3704)	0.60	0.069	0.2006 (0.1452)	0.2739 (0.2178)	0.72	0.172
SCD1	0.8676 (0.8784)	1.3172 (1.7992)	0.64	0.266	0.7727 (0.7134)	0.8298 (1.0251)	0.72	0.822
SREBP1	0.0238 (0.0126)	0.0366 (0.0268)	0.64	0.050	0.0255 (0.0345)	0.0213 (0.0138)	1.19	0.577
ADIPOQ	0.5757 (0.2606)	0.8252 (0.4946)	0.69	0.041	0.4176 (0.3337)	0.4953 (0.2959)	0.85	0.402
ADRB3	0.002 (0.0021)	0.0017 (0.0023)	1.13	0.667	0.0017 (0.0018)	0.0021 (0.0027)	0.80	0.590
FABP4	1.683 (0.84)	1.2587 (0.6681)	1.31	0.068	0.7458 (0.4979)	0.718 (0.4251)	1.09	0.839
GLUT4	0.0463 (0.0462)	0.0241 (0.0192)	1.86	0.035	0.0246 (0.016)	0.0175 (0.0141)	1.45	0.114
LEP	0.0803 (0.0847)	0.0653 (0.0539)	1.24	0.477	0.0189 (0.0151)	0.0222 (0.0321)	1.02	0.643

AA and AT + TT indicate TRIB2 genotypes. “Ratio” indicates mean expression levels of AA where the mean expression levels of AT + TT were set to be 1. Data for UCP1 are not shown as UCP1 transcripts were not detectable in the adipose tissue samples. SD indicates standard deviation

ISSN: 1880-6805