Association between thyroid-stimulating hormone (TSH) and proteinuria in relation to thyroid cyst in a euthyroid general population

Table 3 Odds ratios (ORs) and 95% confidence intervals (CIs) of proteinuria in relation to thyroid-stimulating hormone (TSH) by thyroid cyst

	TSH levels			p	Log TSH	p (goodness of fit test)
	(Low)	(Medium)	(High)	p	Log TSH	p (goodness of fit test)
Total
No. of participants	526	539	530
No. of proteinuria cases (%)	25 (4.8)	30 (5.6)	31 (5.8)
Model 1	Ref	1.21 (0.70, 2.08)	1.32 (0.76, 2.27)	0.325	1.13 (0.70, 1.81)	0.933
Model 2	Ref	1.19 (0.68, 2.07)	1.35 (0.77, 2.36)	0.296	1.14 (0.70, 1.86)	0.370
Thyroid cyst (−)
No. of participants	344	374	352
No. of proteinuria cases (%)	9 (2.6)	22 (5.9)	25 (7.1)
Model 1	Ref	2.39 (1.08, 5.26)	3.06 (1.40, 6.69)	0.005	2.10 (1.13, 3.90)	0.135
Model 2	Ref	2.38 (1.07, 5.30)	3.08 (1.38, 6.86)	0.006	2.06 (1.09, 3.90)	0.647
Thyroid cyst (+)
No. of participants	182	165	178
No. of proteinuria cases (%)	16 (8.8)	8 (4.8)	6 (3.4)
Model 1	Ref	0.55 (0.23, 1.34)	0.37 (0.14, 0.98)	0.037	0.41 (0.18, 0.89)	0.842
Model 2	Ref	0.54 (0.21, 1.38)	0.34 (0.12, 0.94)	0.031	0.40 (0.18, 0.89)	0.849

Ref reference. Model 1: adjusted for sex and age. Model 2: + BMI, smoking status (never, former, current), drinking status (none, often, daily), systolic blood pressure (SBP), triglycerides (TG), high-density lipoprotein cholesterol (HDLc), and hemoglobin A1c (HbA1c). Tertile values of TSH for men and women are < 1.19 μIU/mL and < 1.24 μIU/mL for (low), 1.19‑1.82 μIU/mL and 1.24‑1.96 μIU/mL for (medium), and 1.83 μIU/mL ≤ and 1.97 μIU/mL ≤ for (high)

ISSN: 1880-6805