FTO and MC4R polymorphisms, and selected pre-, peri- and postnatal factors as determinants of body mass index and fatness in children: a thorough analysis of the associations

Table 11 Regression analysis predicting BMI z scores, FMI z scores and FatM z scores in children

Variable	R2	β	F	P-value
Model 1: BMI z scores	0.172		7.02	< 0.001
Paternal BMI		0.26		< 0.001
Highest body weight in pregnancy		0.11		0.16
Mother's age at the child’s birth		-0.13		0.01
Father's education (Reference: higher education)		0.08		0.11
Prenatal stress at least one (Reference: 0)		0.07		0.17
Maternal BMI before pregnancy		0.11		0.15
FTO (Reference: TT)		0.07		0.18
Eating behaviour (Reference: good)		0.07		0.2
MC4R (Reference: TT)		0.05		0.31
Model 2: FMI z scores	0.138		10.24	< 0.001
Paternal BMI		0.21		< 0.001
Maternal education level (Reference: higher education)		0.18		< 0.001
Highest body weight in pregnancy		0.16		< 0.001
Mother's age at the child’s birth		-0.10		0.06
FTO (Reference: TT)		0.10		0.04
ACE at least one (Reference: 0)		0.07		0.19
Model 3: FFMI z scores	0.125		8.09	< 0.001
Paternal BMI		0.25		< 0.001
Maternal pre-pregnancy BMI		0.14		0.006
Mother's age at the child’s birth		-0.13		0.01
Eating behaviour (Reference: good)		0.08		0.15
MC4R (Reference: TT)		0.06		0.21
Paternal education level (Reference: higher education)		0.05		0.30
Model 4: FatM z scores	0.178		9.17	< 0.001
Maternal education level (Reference: higher education)		0.16		0.01
Highest body weight in pregnancy		0.21		< 0.001
Paternal BMI		0.17		< 0.001
Mother's age at the child’s birth		-0.11		0.04
FTO (Reference: TT)		0.11		0.03
Paternal education level (Reference: higher education)		0.06		0.28
ACE at least one (Reference: 0)		0.06		0.25
Eating behaviour (Reference: good)		0.06		0.27

BMI Body Mass Index, FMI Fat Mass Index, FFMI Fat Free Mass Index, FatM Fat Mass in kg

ISSN: 1880-6805