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Association of taller stature with lower cardiovascular disease mortality in Asian people: a systematic review
Journal of Physiological Anthropology volume 38, Article number: 6 (2019)
Adult height can serve as a disease marker. While taller stature has been reported to be linked to a decreased risk of cardiovascular disease (CVD), an influence of the height on CVD is not fully understood in specific populations of Asia, which has a lower incidence of CVD and lower stature than Western populations.
We conducted a systematic review using original articles of prospective cohort studies published in English, via the PubMed database, on the relationship between the height and mortality of CVD, including cerebrovascular disease, in Asian people.
We selected four studies on heart/coronary disease and five studies on cerebrovascular disease. Regarding heart/coronary disease, two studies showed that taller stature was associated with a decreased mortality of heart disease in men or cardiovascular disease in women. The hazard ratios of other studies had not shown a clear significance but a decreased direction of taller stature to the mortality. Regarding cerebrovascular disease, most studies showed that taller stature was associated with a decreased mortality of total cerebrovascular diseases or stroke. In two studies, taller stature showed a decreased mortality of ischemic or hemorrhagic stroke.
Overall, adult height may be inversely predictive to the mortality of CVD, in particular cerebrovascular disease, in Asian people. While this seems to be a similar trend to that of Westerns, further studies are warranted.
In general, human height begins increasing before adolescence and reaches its peak in early adulthood [1, 2]. Adult height is an easy indicator of physical condition and development. Stature is typically influenced by both genetic [3,4,5,6] and environmental factors. Environmental factors include nutrition  and socioeconomic status [8,9,10]. The behaviors of several hormones (i.e., insulin-like growth factor and sex hormones) are linked to genetic and environmental factors . Interestingly, human height can also serve as an indicator of disease. Taller stature is linked to a decreased mortality risk, and in a meta-analysis, increases in adult height by 6.5 cm were reported to be associated with a 3% decrease in risk of death from all-cause mortality . Cardiovascular disease (CVD) is a major cause of death in Western countries and Japan , and with every 6.5-cm increase in height, there is a 6% decrease in death from CVD (including heart/coronary and cerebral disease) .
Human height varies by ethnicity . In Asian countries, both the mean height and the incidence of CVD (cardio- and cerebrovascular disease) are lower than in Western countries . However, it is not clear whether the same relationship between the height and mortality of CVD that have been observed in Western countries is present in Asian countries. In fact, previous evaluations of the relationship between the height and mortality of CVD have been focused on Western populations. In one study, 85% of the subjects were Caucasian and it did not include a sub-analysis of racial differences . Thus, we present a systematic review of the relationship between the height and mortality of CVD in Asian people. Herein, because such studies that investigate the states of CVD often include cerebrovascular disease in CVD, we considered simultaneously the mortality of cardio- and cerebrovascular disease.
We conducted a search of the PubMed database using the terms “height,” “mortality.” and “cohort study.” The search was limited to original articles published in English up to July 5, 2018. The following search formula was used: height[All Fields] AND (“mortality”[Subheading] OR “mortality”[All Fields] OR “mortality”[MeSH Terms]) AND (“cohort studies”[MeSH Terms] OR (“cohort”[All Fields] AND “studies”[All Fields]) OR “cohort studies”[All Fields] OR (“cohort”[All Fields] AND “study”[All Fields]) OR “cohort study”[All Fields]).
The search returned 2309 articles, 69 of which were cohort studies that referred to both height for any age and disease mortality in the title and abstract; we then reviewed the full-text versions of those 69 articles. We excluded irrelevant articles (n = 64) based on lack of information on height (n = 10) or CVD mortality (n = 23) or those which were limited to studying subjects who were suffering from specific diseases (non-CVD) at the start of the study (n = 2). We also excluded a review article (n = 1) and the studies using cohorts from Western countries (n = 28). Five articles [16,17,18,19,20] that described cohort studies in Asian populations were ultimately retrieved (Fig. 1).
We retrieved five eligible studies of the relationship between the height and mortality of CVD (four studies on heart/coronary disease and five studies on cerebrovascular disease) [16,17,18,19,20] (Table 1). Their publication years ranged from 2003 to 2018and included studies from China (n = 1) , Japan (n = 2) [18, 20], and South Korea (n = 2) [16, 17]. The range of subjects’ mean age for the five studies was 30–74 years, the mean men’s height ranged from 155.6–173.4 cm, and the mean women’s height ranged from 144.0–160.7 cm (Fig. 1). The hazard ratios for height on mortality of CVD are shown in Table 2.
Regarding the results of heart/coronary disease [16, 17, 19, 20], taller stature was associated with a decreased mortality of heart disease (in men)  or the mortality of cardiovascular disease (this study included the diseases such as strokes) in women but not in men . There were no significant associations between the height and mortality from coronary disease , myocardial infarction , or ischemic heart disease [16, 17], although all the hazard ratios showed a decreased direction (< 1.0).
Regarding the results of cerebrovascular disease [16,17,18,19,20], taller stature was associated with a decreased mortality of stroke [16, 17, 19] and in women but not in men . Also, taller stature was associated with a decreased mortality of total cerebrovascular diseases , hemorrhagic stroke [16, 17, 20], or ischemic stroke (in women) [16, 18]. There were no significant associations between the height and mortality from hemorrhagic stroke  or ischemic stroke [17, 20], although most the hazard ratios showed a decreased direction (< 1.0).
When stratified by sex in the studies examined both sexes, taller stature was significantly associated with a decreased mortality of cardiovascular disease , stroke , and ischemic stroke  in only women.
Although there found to be limited studies on this topic, Asian populations may show a similar trend to Western populations in terms of an opposing relationship of the height with the mortality of CVD, in particular cerebrovascular disease. If this finding is further identified regardless of ethnic group, the development of height may be more noted and more investigated as a point of the prevention of CVD, besides bodily weight (this is the current mainstream).
There are several previous reports that may partly but causatively explain the inverse association of the height with the mortality of CVD. Taller statute is indicated to have vascular pathophysiological advantages. Inflammation is well-known as a major contributor to the development of CVD, and a high count of leukocyte (an inflammatory biomarker) in the blood is positively associated with taller stature . While the height is affected by genetic factors [5, 6], a variation of CVD-related gene polymorphism (e.g., rs3782886), which decreases inflammation, is positively associated with taller stature . Also, taller stature can induce a large diameter of coronary arteries, leading to an assumption that the large diameter predisposes to prevent the arterial occlusion .
Additionally, Western lifestyles (a lack of exercise with high-energy diet) are also related to an increased risk of CVD [24, 25]. The development of CVD is higher among Japanese-Americans than among Japanese people living in Japan . This residence-based difference is used as an example case that lifestyle is impactful relative to genetic factors. Westernization of Asian countries may be a partial explanation on the relationship between the height and mortality of CVD in both Asian and Western populations.
Of note, in the current review, it appears that the height can have a clear influence on the mortality of cerebrovascular disease and in women. A report revealed the opposite trend among Westerns, wherein the height had a greater influence on the mortality of CVD in men than in women . There are some unique gender differences regarding health outcomes among Asians. The incidence of stroke among Westerns ≥ 75 years old is higher in women than in men , but there is no sexual specificity with regard to the incidence of stroke in Asians . In Asian countries such as Japan, cerebrovascular disease is more developed than coronary disease [15, 29]. These facts may be partly associated with the influence of height on the mortality of cerebrovascular disease and in women observed in the current review.
This review had some limitations. We acknowledged the comparatively small numbers of studies for the review and the small samples of subjects in each study. The outcomes of CVD and cerebrovascular disease were heterogeneous. More data are needed to draw more robust conclusions on this topic.
From this review, overall, adult height may be inversely predictive to the mortality of CVD, in particular cerebrovascular disease, in Asian people. While this seems to be a similar trend to that of Westerns, further studies are warranted.
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This work was supported in part by Jichi Medical University.
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